Mayuri probably takes a shit ton of drugs, right? Both for Important Science Reasons and (less often?) recreationally. I also think it's fair to assume that Akon is THE most qualified person to trip-sit Mayuri whenever he gets too whacked out on something.
It's like Mayuri is in the middle of demonstrating something in a lab w/ a large group of underlings there including Akon, and he's been getting increasingly weird (more than usual lol) over the past hour.
He suddenly spaces out mid-sentence, turns, and starts like. climbing up on the counter and shelves to try and get a closer look at an upper corner of the room - A very normal-looking corner with nothing wrong with it.
He starts talking absolute nonsense about there being some sort of dimensional-rift in there that he HAS to see up close, how have none of you noticed this yet, hellooo, why aren't any of you idiots taking notes about this giant rotating fractal where these walls are intersecting with each-other?!
And everyone else is like frozen in vague fear and unsure of how to approach this situation where their captain is very clearly tripping balls.
Akon just sighs and goes up to the counter and is like *casually tugs at the hem of Mayuri's hakama* "Captain, we can look at the dimensional rift later, I think you took too much of something. You need to go relax and wait it out."
Akon turn turns and tells everyone to pack up and leave, they'll continue this later. Everyone hurries out.
Mayuri: *snaps his head around to glare at Akon, his pupils are so huge that you basically can't see his irises at all* "I don't recall giving you permission to run my schedule--" (pauses, squints at Akon) "Akon, since when did you get surgery to add multiple more pairs of eyes to your face? And they're all breathing."
Akon, tiredly: "Since never, sir. You're extremely high right now."
Mayuri: (Pauses, looks around, rubs at his eyes) "...So there's no rift? Ugh, I knew I took too much of that serum." (tries to get down from the counter, misjudges the distance and almost falls. Akon catches and steadies him.)
Mayuri: (Appreciates this but is also very embarrassed, shoves Akon off) "I'm not some invalid, you know. You don't have to hover." (*Goes to leave, tries to reach for the doorknob when he's still like 5 feet away from it, grabs air*)
Akon, trying not to smile: "Wouldn't dream of it, sir." (He walks with him out the door and down the hall, stealthily floating a hand behind Mayuri's back in case he sways or loses balance)