A Potentially Actionable Component of Innate Immunity in COVID-19
Supplementing NMN can effectively increase and restore NAD + levels in the body, so what is NAD +?
NAD + is a coenzyme. In 1922, British biochemist Arthui harden discovered a magic substance-NAD +.
There are about 20 kinds of coenzymes in the body, including coenzyme I (NAD + / NADH), coenzyme II (NADP + / NADP), adenosylmethionine, ATP, coenzyme A, pyridoxine phosphate, biotin and so on. Each coenzyme corresponds to several or even hundreds of enzymes. Among them, NAD + is the most widely used because it is a coenzyme of hundreds of oxidoreductases. Metabolic activity.
Scientific research in recent years has further revealed that in addition to being a coenzyme of hundreds of enzymes, NAD + maintains longevity proteins and repairs DNA.In 2000, it was confirmed by the scientific community that this substance has an anti-aging effect.
In 2007, a professor at the University of Iowa discovered that NAD + (telomerase) can be converted from oral drugs.
In 2013, Professor Harvard's use of experimental pro-test NAD + (telomerase) for human anti-aging will have milestone effects.
In 2016, NASA awarded iTech Award for NAD + anti-aging scientific research achievements.
NMN (Nicotinamide Single Nucleotide) is the most direct precursor of the longevity protein cofactor NAD + in the human body. Because NAD + itself has a large molecular volume, it is difficult to penetrate the cell membrane and enter the cell, so it cannot directly take up NAD +. Through the process of "precursor transformation", after the human body ingests NMN, once it enters the cell, the two NMN molecules will combine together to form a NAD + molecule. In turn, it raises the level of NAD + in the body to achieve anti-aging effects. Therefore, regular intake of this substance can effectively increase its content in the body, thereby helping humans repair DNA damage and delay aging.
In addition, NAD + is also the key to maintaining the normal function of the immune system.
However, with increasing age, NAD + in the human body will also decrease, and the body's functions will gradually decline. Supplementing NMN can effectively increase and restore NAD + levels in the body.
Previously, an Iranian team researched that the new coronavirus will "compete" for NAD + in the body. The large amount of ROS generated by the "inflammatory storm" it brings will consume a lot of NAD +, and supplementing NAD + will help the new crown treatment.
In the face of the rampant epidemic, countries have begun to find effective treatments. In this process, scientists from many countries have proposed that exogenous supplementation of NAD + will become a feasible and effective treatment for new coronary pneumonia (COVD-19) Preventive measures.
Although there are differences in the details of many related theories, the core idea is relatively consistent: the new coronavirus (SARS-CoV-2) infection theoretically activates polyadenosine diphosphate ribose polymerases (PARPs) in the host cell, accelerating the consumption of NAD +, which leads A variety of physiological problems, so supplementing NAD + can alleviate or even treat a variety of new coronary symptoms. However, without the support of experimental data, the statement will always be a statement and cannot be applied to the clinic.
The Brenner team at the University of Iowa completed and published their experimental results on the relationship between NAD + and the new coronavirus. They found that exogenous supplementation of NAD + may be the key to helping the innate immune system overcome the new coronavirus.
Intermediate; cosmetic raw materials-whitening agent; cosmetic grade; organic chemicals; pharmaceutical raw materials;pharmaceutical raw materials; other sugars; vitamin derivatives; pharmaceutical intermediates; food additives; cosmetic rawmaterials whitening raw materials; raw materials; raw materials; chemical; chemical; Japanese Chemical raw materials; whitening freckle raw materials; vitamin C ethyl ether; medical raw materials; cosmetic daily chemical raw materials; chemical raw materials-1; pharmaceutical raw material intermediates; antioxidants; biochemicals; chemical intermediates; daily chemical rawmaterials / cosmetics; cosmetic raw materials ; VitamineCderivative