it's not great. put simply: the story has some good ideas and Wilson has a knack for imagery and one-liners, but the execution is remarkably wooden and the theming has huge usamerican-shaped holes in it. Overall I would not recommend. Details below.
In a literary sense it fails constantly by telling and not showing, showing and then just telling anyway, and spoiling its own twists 'n' turns by telling you how important certain details are. Writing things like "this decision would save four billion lives" and "this small detail caused a huge misunderstanding later on" is not evocative or even effective foreshadowing. It is hitting me over the head with a club that has "consequential" written on it because you think I won't notice otherwise.
Most of the book also does a middling-to-bad job of transitioning between locations and perspectives, jerking you around like a pinball and not really justifying why. Eight paragraph chapters will spend fully half their space just getting you up to speed on who is where and what they're doing there, and then rush to explain why this is relevant before spiriting you away to some other unrelated event. I think the intended effect is an impression of a big, multifaceted story with all sorts of moving parts. In practice, it just makes the book feel less like a story and more like a series of disconnected events. Very inelegant and crass narrative flow.
As prose it's not especially good or bad. There is an over-reliance on and persistent overuse of parentheticals and em dashes -- at least one per page -- which is sloppy and in many cases outright boring to read. There are occasional footnotes at the bottoms of the pages (the book is masquerading as a government report (just like the original andromeda strain)) and they tend to be placed well, offering in-setting context as needed and more than once allowing the story a moment to poke fun at itself. But this is not always successful.
Themes and morals are not amazing, but not the worst. For a novel only a few degrees separated from Crichton's Congo it has a very well-formed and carefully considered stance on the uncontacted indigenous peoples of Brazil, clearly parallelling the area's historical relationship with exploitation and colonialism with a mad scientist's crazed plotting to build a space elevator and unleash the grey goo scenario. This is probably in large part due to Wilson's own experience as a Cherokee citizen. But the theme doesn't quite land as anti-colonial because the novel cannot let go of imperialism, because it centers the US government as a major positive force.
This is where the usamerican-shaped holes come in. Attempts to patch them are made, assertions that the technology of the outside world does not make us better than uncontacted indigenous peoples, acknowledgements that the US government spying on the amazon rainforest and sending ground squads (and later, scrambling fighter jets) into Brazilian territory is in some way going to cause all sorts of horrific problems. Unfortunately, this is muddied by an air of regrettable necessity surrounding US intervention and cloying assertions to the tune of "there's only one race: the human race." Several times the mission is jeopardized by the single Chinese member of the team rightly fearing that she cannot trust these lackeys of the US Government, framing it as some moral failing to not work together harmoniously on this illegal black operation organized by a hostile foreign power. There's also an incredibly tasteless amount of shade thrown at the PRC for making their own space station after being intentionally left out of building/operating the ISS in this same chastising tone.
Back on theme, we've also got a horrid one about parentage and children. This is already a bad idea because of how overused the concept is, but it's made worse by the story not even trying to connect it to the action. It would be so easy to do, just add some lines about how the plot is about securing the future or making a better world for the future. But it just never happens. There's also an incredibly forced romance subplot between the protagonist and the only non-hostile, non-inconsequential woman in the story who isn't chinese.
All that said, the ending action sequence is killer. Wilson knows how to make an exciting mental image and narrates confrontation very well. Resolution is a little too neat and it plays a nasty trick to wiggle out of promised consequences but hey, even sticking the landing partway is an excellent outcome for such a stilted book.
On the novel as a sequel, I really like the ideas at play. Either Crichton was always in that kind of hokey comic book space (not unlikely) that Wilson seems to thrive in, or Wilson has really dialed into Crichton's kind of sci-fi nonsense. This expansion of the real world into a proper "andromeda strain setting," with a rewrite of global history to secretly be about the andromeda strain and sci-fi tech like functional brain-computer interfaces, would make for a killer conspiracy novel. If Wilson had been interested in using this as anything but set-dressing, that is. Would also make for a good SCP article.
I'd rate this 2/5. Not utter dogshit, but a pretty slapdash book, admittedly with some fun ideas. If I hadn't read it in one sitting to get it over with i would not have picked it back up.