Q: Are you really scared during every fight with demons? We got into his mind to find out the answer to this question. He seems to have noticed it.
Game of Thrones Daily

★
Misplaced Lens Cap

Love Begins
dirt enthusiast
Acquired Stardust
Today's Document
Cosmic Funnies
Sweet Seals For You, Always
Stranger Things
we're not kids anymore.
Monterey Bay Aquarium
PUT YOUR BEARD IN MY MOUTH

titsay
i don't do bad sauce passes

@theartofmadeline
No title available

shark vs the universe
Alisa U Zemlji Chuda
hello vonnie
seen from United States
seen from United States
seen from United Kingdom

seen from Malaysia

seen from United States
seen from United States

seen from United States

seen from Singapore

seen from Argentina

seen from Argentina
seen from Kazakhstan
seen from Argentina
seen from United States
seen from United States
seen from Netherlands

seen from United States
seen from United States
seen from United States
seen from United States
seen from United States
@nu-so
Q: Are you really scared during every fight with demons? We got into his mind to find out the answer to this question. He seems to have noticed it.
Giggled to myself while making that third slide
“On social media you only see people’s highs and not their lows so you get the impression that everybody else only experiences highs which can lower your self esteem” idk what social media you’re on but it isn’t like that for me
lowkey regret turning down my friend when she asked me to make out
i mean we were both drunk asf when she asked, so its probs the best I did
but damn
fruit edition
are you a strawberry or raspberry person? a lemon or lime person? a mango or peach person? a pear or apple person?
Didn't realize they made emergency thermal blankets for babies
It's scary to think about babies in an emergency but I guess it's a crazy world out there
Emergency baby
[Francisco de Goya]
no but im thinking about the videos diaries now bcos for like 20 years Grace and the other astronauts were all remembered as the heroes who went on a suicide mission to save the sun? which is impressive on its own but once the beetles come back and some of the videos get released everyone is like :O :O :O bcos not ONLY did Ryland Grace nobly volunteer to go on a suicide mission to save the sun, he did the whole mission by himself after the other astronauts died and made first contact with an alien species while he was at it?? he's basically the best guy in history??
but then someone leaks the Full Unadultered Ryland Grace diaries and there's gonna be various Realisations along the lines of
oh my god he didn't volunteer. oh god he was so angry & miserable and lonely up there. they just sent this sweet man to die in space against his will. oh we're all alive because they killed this poor man. okay.
oh my god he was so stupid he was such a stupid dork he nearly got us all killed so many times
the sooner I don't have to live with my super skinny roommate the better. she's triggering every fucking fatphobic thought towards myself
i need to start working out again holy shit
I stop for two weeks, and my mental health has gone to the DOGS
TRANS WOMEN: HERE'S SOME SHIT YOUR DOCTOR WONT TELL YOU ABOUT HRT
1. Progesterone: not for everyone, but for many people it may increase sex drive and WILL make your boobs bigger. Also effects mood in ways that many find positive (but some find negative). Most doctors won’t prescribe this to you unless you ask. Most trans girls I know swear by it.
2. Injectible estrogen: is more effective than pill or patch form. Get on it if you can bear needles bc you will see more effects more quickly.
3. Estradiol Cypionate: There is currently a shortage of injectible estradiol valerate. There is no shortage of estradiol cypionate. Functionally they do the same shit.
4. Bicalutamide: This is an anti-androgen that has almost none of the side-effects of spironolactone or finasteride. The girls I know who are on it are evangelical about it.
@euryale-dreams
Are there HRT medications that don’t increase blood clot risk? I’m already at risk because of my blood pressure, and my doctor won’t prescribe HRT that increases clot risk while I’m on the medication - and I may never not be on the medication.
Absolutely.
The concerns surrounding venous thromboembolic events as a side-effect of hormone replacement therapy can mostly be traced back to one particular study known as the Women’s Health Initiative. This study was an enormous undertaking which, unfortunately, demonstrated significant adverse effects of the hormone therapies studied. As a result of this the use of hormone replacement therapy in postmenopausal cis women was dramatically reduced as the medical community began to question whether or not the therapy caused more harm than good.
Naturally, trans women have been suffering from this fall-out ever since.
What physicians seem to fail to recognize is that the study examined a very specific hormone regimen which was, arguably, outmoded at the time the study was conducted: It examined the use of conjugated equine estrogen (Premarin) with or without the use of medroxyprogesterone acetate. Neither of these drugs is regularly used for the treatment of transgender women.
The estrogen most commonly used to treat transgender women nowadays is 17β-estradiol either in pill form or in the form of a sticky patch that you apply to your skin. Esters of estrogen (e.g. estradiol valerate) are also sometimes used either in a pill form or as an intramuscular injection.
Transdermal estradiol patches are the gold standard when it comes to treating women who are at high risk of a venous thromboembolic event. It simply does not increase the risk of developing a venous thromboembolism. The only thing you should keep in mind is that patches are not always well tolerated because of the lifestyle changes required to keep them from falling off and the fact that they tend to irritate the skin.
Fortunately, oral 17β-estradiol appears to be safe, regardless of the increased risk. At least one large study has shown that the use of oral estradiol in trans women is not associated with venous thromboembolic events. An individual woman’s risk would need to be substantial in order to contraindicate the use of oral estradiol.
For those who have significant risk of venous thromboembolism because they have had a previous thromboembolic event, because they are paralyzed, or because of some other factor it is good to know the relative risk between oral and transdermal estrogen. The latest research indicates that the use of transdermal estrogen lowers your risk of a thromboembolism to 80% of what your risk would be using oral estrogens.
It’s difficult to find hard numbers regarding the relative risk of venous thromboembolic events with regards to hypertension. The best I could find after an hour or so of searching was this study regarding VTE in lung cancer patients. Hypertension increased the risk by a factor of 1.8.
However, to put that into perspective being of African descent increases your relative risk for deep vein thrombosis by a factor of 1.3 when compared to Europeans. Europeans are, themselves, at increased risk when compared to Asians and Pacific Islanders by a considerable margin: a four-fold increase.
I should point out that being ‘male’ is also a risk factor for developing a thromboembolism and hormones are likely to be a contributing factor. Also, menopause is another serious risk factor. Given this information it is likely that the use of transdermal estradiol will lower your risk of thromboembolic events significantly.
As far as the anti-androgen is concerned: The primary use for spironolactone for cisgender people is as an antihypertensive.
Even if the risk of thromboembolism was truly significant with modern hormone replacement therapy it wouldn’t justify what your doctor is doing to you. The fact is that mortality in the transgender community from suicide–caused in part due to the lack of access to hormone therapy–is substantial. The quality of life lost when a trans woman is denied hormone therapy is substantial. The fact that your doctor does not appear to be taking this into consideration when they weigh the risk of thromboembolism against not receiving necessary medical care is deeply concerning.
I strongly recommend that you seek a doctor who is more sensitive to your medical needs as a transgender woman.
Edit: Fixed a minor, but embarrassing, error.
oh wow this is so helpful & good info
Everyone who cares about transfem people please reblog this
this was really fucking helpful
I know a lot of trans women dont have acess to information like this and its very helpful.
420 years ago, on 4/20, the moon was made of weed.
This is the only day you can reblog this. Do it for Weed Moon.
I saw this and had to save this image cause I definitely have a few readers like this.
the project hail mary universe is one of the only ones out there where orpheus turning around actually saved eurydice btw
The best part of the beach is pretending to fight the ocean by beating the shit outta them waves
I always lose but it makes me feel important, and it’s fun
I'm pushing 30, why
bro my physics professor can SUCK MY DICK
what do you mean that you're combining two concepts - THAT WE'VE NEVER DONE IN CLASS IN HW NEVER - on the exam
and you NEVER GAVE US A HINT
a whole fucking study guide, and it has not useful AT ALL.
what am i paying this money for. this is stupid. i'm gonna fail the fucking class