Sans titre

[uss-edsall]

Does anyone have this picture

But it’s a parody of Master and Commander’s opening title

I swear I have seen this before and I cannot for the life of me find it

[kesslersymbolic]

This image?

[uss-edsall]

YES

[eddardsharpe]

[bacony-cakes]

PNG'D! (i didn't know the font so this is taken directly from the image)

+ bonus italian navy vessel

[catgirl-kaiju]

[reasonsforhope]

FDA just approved the world’s first once-a-week insulin injection for diabetics, a major development for patients who rely on daily insulin

For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again

"For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again tomorrow.

That routine just changed.

On March 26, 2026, the U.S. Food and Drug Administration approved Awiqli (insulin icodec-abae), developed by Novo Nordisk, as the first and only once-weekly basal insulin ever approved for adults with type 2 diabetes in the United States.

This is not a minor update to an existing drug.

It is the first entirely new class of basal insulin to reach U.S. patients in more than two decades.

Instead of injecting insulin every single day, people with type 2 diabetes using Awiqli will only need one shot per week, on the same day, every week.

That means reducing from 365 injections a year down to just 52.

For anyone who has ever felt the weight of that daily ritual — the anxiety of forgetting, the physical discomfort, the constant reminder that their body needs help — this approval represents something much bigger than a dosing schedule.

It represents relief.

How the Drug Actually Works

Understanding why this injection lasts a full week requires a quick look inside the body.

Most traditional basal insulins are absorbed into the bloodstream and begin breaking down within 24 hours, which is why patients need a fresh dose every day to maintain stable blood sugar levels.

Awiqli works differently.

Its active ingredient, insulin icodec-abae, is engineered to loosely attach to a blood protein called albumin, which is found naturally and abundantly in the bloodstream.

This attachment creates a slow-release reservoir.

Instead of flooding the system and fading fast, the insulin releases gradually and consistently over an entire seven-day period, keeping blood sugar in a healthy range around the clock...

The FDA reviewed and ultimately declined to approve it for people with type 1 diabetes, citing concerns about a modestly increased risk of hypoglycemia in that population specifically.

Some regulatory agencies in other countries, including the European Union, Canada, Australia, and Japan, have approved Awiqli for both type 1 and type 2 diabetes, but for now the U.S. approval is limited to type 2...

What Comes Next

Awiqli is not standing alone in this space for long.

Eli Lilly is developing its own once-weekly basal insulin, called efsitora alfa, which is currently in late-stage clinical trials.

If that drug also earns FDA approval, it would give patients and doctors two once-weekly options to choose from, allowing for personalized decisions based on a patient’s health profile, insurance coverage, and individual response.

The broader direction of travel in diabetes care is unmistakable.

Fewer injections, smarter formulations, and better integration with digital tools like continuous glucose monitors and insulin-tracking apps are all converging toward a future where managing diabetes requires less daily mental effort without becoming any less medically precise...

A Small Shot With Large Implications

It is easy to look at a once-weekly injection and see only a scheduling change.

But the science behind Awiqli, the scale of the ONWARDS trials, and the consistent satisfaction reported by patients all point toward something that matters far more than convenience.

Diabetes management has always asked a lot of people.

It asks for daily vigilance, daily discipline, and a daily willingness to confront one’s own condition, sometimes in uncomfortable or inconvenient circumstances.

Anything that reduces that load, without reducing the quality of care, is worth taking seriously.

For the more than 37 million Americans living with diabetes, and the hundreds of millions more around the world, a simpler weekly routine could mean the difference between a treatment plan that works on paper and one that actually works in a person’s life.

That is the real significance of what the FDA approved on March 26, 2026.

Not just a new drug.

A new way of keeping people healthy, one week at a time."

-via Science Aim, March 29, 2026.

[eugeniedanglars]

randomly remembered “i have d cups, grandpa. the waitress thinks you have dementia” tonight so i decided to find the original tweet again and

[refrainboy]

[ID: A Tweet and self-reply by Twitter user Akira.

The original Tweet says "At a certain magnitude of cunt severity, getting misgendered by your family stops hurting and starts being funny. I have D cups, Grandpa. The waitress thinks you have dementia."

The reply reads: "UPDATE: she was right". End ID]

[kitstacean]

So, one thing I'd like to note here is

One of the lesser known early symptoms of dementia is that people start being more disagreeable.

Part of this is probably the natural result of being increasingly confused and upset day to day constantly. Another possible thing is that the same mechanism that causes dementia is also attacking the part of the brain that does emotional regulation.

And the thing is this is super early stage. By the time they stop remembering when's the last time you met, it's already way too late. But if an older person in your life starts acting way more like a cunt for literally no reason, and it's not particularly in character for them, it really might be worth testing for dementia or Alzheimer's because you have a lot more options catching it earlier.

[vaspider]

this is a good argument for not being an asshole: people will notice sooner if you get more argumentative.

[muffinly]

^ that is a great point

[tall]

[stunningpicture]

Failed panoramic.

[ianre-d]

define failed

[lonelovebird]

dude

[roguesquirrel]

the dream is collapsing

[labelleizzy]

Inception-ing the ocean

[onlytiktoks]

[aniseandspearmint]

Asdfghjkl her perfectly straight face and even tone throughout should win an AWARD

[sandmandaddy69]

[sigmaleph]

what's this 'wife' business? nobody calls him Prince-Consort Mario

[rustingbridges]

if Bowser kidnapped my plumbing client, I would be saying “wahoo” as long as those hours were billable

[aro-ace-chaos]

I love Project Hail Mary, both the book and the movie, but the amount of shipping content I've been seeing for it recently really irks me.

I know a lot of people are just having fun, and that's all well and good, but there's also a reason that Grace is so aroace-coded, and it's intentional.

Spoilers for the book and the movie below, proceed at your own risk. However, this is a very important discussion to have imo, because I've seen a concerning rise in amatonormative responses to this story.

Grace demonstrates a massive amount of love, and none of it is rose. Platonic love for Rocky. Love for science and knowledge, love for humanity and for other people (his students, his friends). He is a full and complete person full of love and hope and ambition, and NONE of it has to do with romance. And I think that is very intentional.

I think that Project Hail Mary is inherently anti-amatonormativity. Like the fundamental message of the book is about all those other types of love and hope and it's beautiful. That's why it resonated with me so deeply, as a nonpartnering aroace. Like, finally, a beautiful story with practically no romance in sight, that doesn't infantilize Grace for being single, or tries to hook him up with someone in the end. It doesn't treat romance like the end all be all. He doesn't need that, and that's great for him.

His happily ever after is living on an alien planet with his alien best friend Rocky and Rocky's alien partner, Adrian, and teaching little aliens. Because Grace is a teacher. He gets his joy from teaching more than anything. It's a beautiful ending. Grace is happy and content without a single other human around, because he has his best friend and his students. Like, it makes me cry just to think about, because it's beautiful.

And then I see people shipping him, and it's like they totally missed one of the messages of the story.

You probably remember when Stratt tried to justify forcing Grace to go on this suicide mission because he had no spouse, no family, and not even a dog, right? You do realize that it's bad logic, right? Like, she did a bad thing. Yes, it saved humanity, but it was a bad thing to do. And she definitely would have sent him even if he did have a spouse or a family or a dog, because he was literally their only chance at saving humanity.

Stratt's excuse about not having a family etc is a bad thing. The story portrays this as a bad thing.

The message the book is conveying here is: "people are not worth less just because they are single".

So it fucking kills me to see people shipping Grace. There was a huge message here about how people have worth because they are people, and how Stratt did an extremely reprehensible thing to save humanity. There's a message here about platonic love and love for the Earth and humanity and hope for the future, and it's beautiful. It's truly beautiful, and I think it's why so many aroace people resonate so deeply with this book and movie.

As I've said before and I'll say again, if the only way you can interact with a fandom involves shipping, you should consider how amatonormativity may be affecting you and your biases. There is so much more to life than romance and shit. Try to get a little more creative with the way you engage with media, and also just the way you view life in general. There's so much more out there than rose relationships.

[despazito]

[teaboot]

The End For You Is Near....

[teaboot]

Stop Congratulating My Haircut

[kawuli]

random PSA, I know a lot of people use duckduckgo as a Google alternative search engine, but it always kind of annoyed me when I was using it because it felt like No Name Brand Google

I have switched to using Startpage.com and vastly prefer it. for one thing, instead of displaying an "AI summary" at the top of the search results (unless you turn it off, yes I know), it displays the first paragraph of the Wikipedia article, with link, whenever it finds one that's relevant.

also a waaayyyyy better sense of design than duckduckgo

also private, European based, least annoying search I've used lately (RIP old "don't be evil" Google)

[yomikoreadsbooks]

Keeping a list of Google alternatives just in case…

[saxifraga-x-urbium]

i have one of those, scraped from multiple different rec posts:

Search Engines

Infinity Search is an alternative search engine with a special focus on privacy

DuckDuckGo is a popular search engine for those who value their privacy and are put off by the thought of their every query being tracked and logged. Uses bangs, ![site] for in-page search (sells your data to microsoft and draws from fucking bing)

WolframAlpha is a privately owned search engine that allows you to “compute expert-level answers using Wolfram’s breakthrough algorithms, knowledgebase, and AI technology.” A data search engine.

Boardreader is a search engine for forums and message boards. It allows you to search forums and then filter down results by date and language.

Based in France, Qwant is a privacy-based search engine that won’t record your searches or use your personal details for advertising. Uses “&” as a bang search.

Another privacy-based search engine is Search Encrypt, which uses local encryption to ensure that users’ identifiable information cannot be tracked. Metasearch across multiple engines. 

Offering unbiased results from several sources, SearX is a metasearch engine that aims to present a free, decentralized view of the internet. Can be self-hosted. 

Gibiru’s tagline is “Unfiltered private search” and that’s exactly what it offers. Requires AnonymoX Firefox add-on for privacy. 

Disconnect allows you to conduct anonymous searches through a search engine of your choice.

Swisscows provides fully encrypted searches to protect your privacy and security. Built-in violence/porn filter cannot be overridden. 

MetaGer offers “Privacy Protected Search & Find” through its anonymised search. A plugin will allow it to be made a default.

Gigablast is a private search engine that indexes millions of websites and servers real-time information without tracking your data, keeping you hidden from marketers and spammers. Variety of filtration and refinement options for searching. 

Oscobo is a search engine that protects your privacy while you search the web. By not using any third-party tools or scripts, your data is protected from hacking and misuse. Has a Chrome extension to allow use in toolbar. 

https://search.marginalia.nu/ an independent DIY search engine that focuses on non-commercial content, and attempts to show you sites you perhaps weren't aware of in favor of the sort of sites you probably already knew existed. Use old-school searching rather than query-based for the best results. 

https://www.mojeek.com/ 

https://wiby.me/ - It’s goal is to index as many personalized websites as possible, and NOT commercial sites. 

https://4get.ca/ it works a lot like SearX, but honestly better. It doesn’t have its own index, but pulls from many others. I think it’s the best for research, since it allows you to search for answers from different indexes, is easy to configure, add free, and avoids censorship as much as it can.

https://www.searchenginemap.com/ for more on how search engines relate to each other.

https://yep.com/ is a crawler

https://www.etools.ch/ retrieves from Google, Mojeek, Bing, and Yandex, like Searx

https://www.dogpile.com/ 

https://searxng.org/ (next gen Searx)

https://luxxle.com/ - possibly conservative?

https://presearch.com/ - good for academic?

https://kagi.com/smallweb - free/randomised Kagi.

Other Searchers

www.refseek.com - Academic Resource Search. More than a billion sources: encyclopedia, monographies, magazines.

www.worldcat.org - a search for the contents of 20 thousand worldwide libraries. Find out where lies the nearest rare book you need.

https://link.springer.com - access to more than 10 million scientific documents: books, articles, research protocols.

www.bioline.org.br is a library of scientific bioscience journals published in developing countries.

http://repec.org - volunteers from 102 countries have collected almost 4 million publications on economics and related science.

www.science.gov is an American state search engine on 2200+ scientific sites. More than 200 million articles are indexed.

www.base-search.net is one of the most powerful researches on academic studies texts. More than 100 million scientific documents, 70% of them are free.https://cosine.club/ is an electronic music similarity search engine

[viralfrog]

[theriu]

Guys I was GIDDY with excitement when I realized the stick is how they figure out the standing-up perspective!!! I always figured people doing this stuff just had magical perspective powers but that makes SO MUCH SENSE what a cool tool!!! Amazing job!

[wifegideonnav]

“bits to use in everyday conversations”

[quo-usque-tandem]

Yuanyang rice terraces, Yunnan, China

[sometiktoksarevalid]

[kevinbparry]

Testing a new mirror trick

[cosmonaut-observer]

If you live in the UK you need to see this

Protect Internet Freedom from now until forever. It's important existentially! Americans stand with UK citizens in our struggle against government censorship

[russettrush]

Growing up in the online world: a national consultation

We are consulting on further measures to prepare children for the future in an age of rapid technological change. This includes potential ag

Got the link via @finalducc

If you live in the UK, please be sure to take part in this!

[fading-bisexual-queen-milkshake]

@daysleftofsecondterm

[starlightshadowsworld]

You guys have my whole heart for sharing this I had no idea will be filling this out and encourage all my fellow brits to do soo too. If you’re not from the UK please keep sharing this around we have till the 26th May to submit these in.

This whole thing was set up without our say we all need to make sure we’re heard.