Blog of stuff I like @purple-lilly - Tumblr Blog

following people who are into wrestling is just like "holy shit johnny appleseed just hit burner hurtzog (evil artfilm director-themed wrestler) with the Prostate Puncher 5000! can't fucking stand that guy!" like all day long

wunderwirker

orange-catsidy

brxdyking

zestyeel

I'm normal about this game I promise

dalishbee

quick leliana

o0kawaii0o

Hero of Time

#ocarina of time #link

yamato-usagi3284tloz

#link #ocarina of time

d1n0pwr

Tunic! 🦊

My favorite game

tasya2345

#hotline miami

grwvy-rwby

Team RWBY is ready for the beach!

I've had a screen shot of this 'beelieve bakini' (under the cut) saved on my phone for like two years with the intention to draw Yang in it. I've sort of succeeded.

thegorgonist

Ocarina of Time was my first Zelda game and to me Sheikh is an integral element of the magic it cast over me.

beemovieerotica

the cognitive dissonance from people who want the products of modern medicine but get weird about animal research. like im sorry but this is necessary for the survival of the society we currently live in. and the scientists who work on these things are not evil cackling psychopaths. anyone you talk to in animal research has incredibly complex feelings about their work and incredibly complex relationships to the animals in their care. there are regulations and oversight and penalties in place to make the work as humane as possible and scientists are overwhelmingly the ones enforcing and advocating for better care.

beemovieerotica

@velvetdemon I'm doing a full reply because I want to give this question the time and space it deserves, and I really do appreciate your curiosity about this.

The short answer: It is deeply unethical. There are nowhere near enough willing patients in the world to be able to do this, and it would be criminal to put them through this.

The long answer: The one side of the equation you're focusing on is: how much of a drug is too much, to the point where it will cause negative side effects or even death? And this is crucial to know. But it's not just a matter of finding out the lethal dosage of a heart cholesterol medication, you need to know that it can actually lower the cholesterol of any living thing. There is no way to know this without giving it first to...a living thing.

But beyond this, I need to emphasize: The goal of a drug trial is to effectively cure people who are already suffering from disease, who are living on limited time.

Drug trials don't just happen on any member of the public, they need to happen specifically on people affected by the disease you're trying to treat. There is at any time a very limited and very marginalized population of the world affected by early onset, familial Parkinson's disease. Because you cannot ethically induce disease in a human being, you are working with, speaking with, and helping patients and their families who are hopeful and desperate for a cure.

If you were to jump straight to human trials from petri dishes, not knowing absolutely anything about how the drug functions in a living, breathing animal body, it would look like this:

We didn't know that minute quantities of the drug interact lethally with x, y, z medication that people are commonly also taking. X number of patients have died as a result.

We didn't know that the drug is fatal to people with [common variant] in their genetics. X more patients have died.

We didn't know the drug exacerbates x, y, z chronic illnesses. X number of people have acquired permanent, lifelong disabilities.

We didn't know the best way to deliver the drug, so we tried multiple ways: the people who received it intravenously are now suffering from a painful, costly, and debilitating condition that did not happen with the ingested form.

I could go on, and on, and on.

The vast majority of these problems can be nearly or almost entirely averted by testing other animals first.

These are all people who possibly could have waited for the normal progression from animal testing to human testing and thus received better outcomes. Some people will pass away in the time it takes to get to that point, and that's heartbreaking, and we all wish science could be faster.

But the cost of expediting science could mean a life of profoundly greater suffering or an even shorter life than the one where no intervention happens at all. And at that point, you have completely exhausted your trust, your goodwill, and your patients' hope, after you've failed to do anything or even worsened the lives of people who are already deeply suffering.

manslaughter

hi, i’m an animal research professional. making sure laboratory animals stay alive, healthy, and enriched has been my full-time job for several years now.

animal research is not the mad scientist wild west that PETA wants you to think it is. there are extremely strict federal laws in place to protect the well being of these animals. animal welfare organizations like AAALAC ensure that lab animals are treated with dignity & respect and are given enough specialized care & enrichment to be happy and content in captivity, just like AZA accreditation with zoos.

not a single animal from a zebrafish to a mouse to a dog to a macaque goes unaccounted for. if an animal gets moved to a new cage, paired for breeding, has a procedure performed on it, gives birth, gets sick or injured, dies, etc. it is legally required that this information is recorded and kept on file for the US federal government to access. failing to record & retain this information is very much punishable by US federal law.

let me tell you - if you abuse or kill an animal, even a mouse - you are almost certainly getting both fired & blacklisted from the industry. if you abuse or kill a more ‘advanced’ animal, such as a dog or monkey, you will likely face criminal charges. killing a monkey is as serious and disastrous as a nuclear meltdown. you are expected to reasonably explain every illness, injury, or death of an animal under your care. you must record all of this information. animals that are clearly suffering with low QOL are required to be euthanized according to AVMA guidelines.

research animals are highly expensive. yes, even the "lesser" animals like mice. the cheapest mice will run you a few hundred $ per individual, with some of the most expensive mice i've cared for being $25,000 per individual. in research we have the "three Rs" - reduction (reduce amount of necessary animals to a minimum), refinement (refine processes to ensure research is accurate and animals feel no pain or distress), and replacement (replace animals with non-living research models as they become available). i can assure you no proper research team is wasting animals (*do not* say "b-b-but elon musk--" his research team is actively being investigated for animal abuse by the government).

research methods that do not require live animals are currently being looked into & efforts spearheaded by - you guessed it - the animal research industry itself (notice how the animal rights people are strangely silent & unhelpful when it comes to this?) but current technology is rudimentary and does not compare to live animal models.

some research animal fun facts (US edition):

all species of animals are only allowed to have one single major surgery performed on them in their entire lifetime.

institutions with nonhuman primates must have a behavior program in place (run by knowledgeable primate specialists) to ensure that they are happy and receiving enough daily enrichment and social interaction.

institutions with dogs are required to have physical exercise programs in place. this means every individual dog gets a substantial amount of leashed AND free-roaming exercise daily, including playgroups with other dogs.

a majority of nonhuman primates get to retire to sanctuaries like peaceable primate sanctuary, and almost all dogs get retired and adopted out by organizations like homes for animal heroes. some institutions will also adopt out unneeded young rabbits, guinea pigs, rats, etc.

some strains of mice glow neon green (or orange or blue) under UV light. this is not harmful to them and is commonly seen in cancer research.

so yes, you can rest knowing that laboratory animals are treated with the utmost respect by their caretakers. and you can stop this awful, ignorant talk of human experimentation that will only end in the abuse of nonwhite people, LGBT people, disabled people, indigenous people, and so many others. please just take a look at this wikipedia page if you think “ethical” human experimentation can exist.

bovid-beauty

The rule could have heavy impacts towards trans people across society.

Last week, the Trump administration quietly released a sweeping new federal rule that would use funding threats to force institutions across the country to reject transgender people. The 400-page proposed regulation would codify the administration's anti-trans executive orders into binding federal policy, imposing a blanket prohibition on federal funds going toward "gender ideology"

The proposed rule, formally titled "Regulation for Federal Financial Assistance," rewrites the government-wide framework governing all federal grants across every agency. Among its most consequential provisions, it requires that before a federal grant recipient can receive money, the award must pass a "pre-issuance review" conducted by a political appointee—not a career expert or peer reviewer—to ensure it is "consistent with applicable law, Federal agency priorities, and the national interest." The regulation explicitly instructs these appointees to screen for "denial by the recipient of the sex binary in humans or the notion that sex is a chosen or mutable characteristic." [...] An institution that acknowledges transgender people exist—through its policies, its training, its healthcare, its bathroom access, its HR procedures, its name-change processes—could be deemed to "deny the sex binary" or to “support the notion that sex is mutable” and have its federal funding blocked.

Importantly, the gender ideology prohibition has no age limitation—hospitals could be targeted not just for providing care to minors but for providing gender-affirming care to adults, because prescribing hormone therapy to a transgender patient of any age could be deemed promoting the belief that "sex is a chosen or mutable characteristic."

junequeer

THIS IS OPEN TO COMMENT UNTIL JULY 13, 2026

featherandstorm

This is all very bad and horrible, but I want to be clear that it’s worse and more sweeping than just eliminating trans research.

This torches everything. And I do mean everything.

A very abbreviated list of its ramifications include (but are not limited to):

ending funding for ALL DEI related initiatives

allowing the government to terminate grants at any point for any reason

preventing researchers from publishing, going to conferences, and being part of academic societies

requiring that topics must support the president’s agenda.

What this means, and if anything I’m under selling it, is the death of science and research in America. It allows the government to restrict any topic they please at a whims notice, putting officials who have no background in the topic in charge of deciding funding continuity. It controls what gets researched and if/how researchers are allowed to share their discoveries. There are no books to burn if the government never allows them to be written. This is fascism plain and simple.

Please, if you only ever write one public comment, this is the one to do.

genderkoolaid

Bringing back this guide to writing an effective public comment. This gives you the basics you need to know, what you need to include, a basic outline you can follow, etc.

Public comments are not a vote, it is a chance for you to say "here is an issue with this law I think you need to address" and provide justification for legal challenges if it goes forward:

"Comments raise the bar that agencies have to meet when making a rule; “if an agency fails to adequately respond to significant, relevant comments in a final rule, members of the public may seek to challenge the rule in court on that basis and claim it could be struck down.ˮ"

But also, if possible, don't stop at writing a comment. Don't stop at calling your representatives. You should ideally be talking to people in your community about this and organizing resistance on-the-ground; there is a good chance people are already doing that even if you aren't hearing about it.

cherrispryte

Some added 101-level context from someone (me) who’s worked in federal grantmaking for 20 years and is literally certified on this document - this is a document that governs all federal grantmaking. It’s been around for over a decade and is a mega-document that combine multiple previous smaller documents that have been around for ages. It is updated every few years and generally the updates are minor - a notable change in the previous update was raising the small procurement threshold from $10,000 to $15,000 for example. Deeply dry boring minutiae that no one outside of federal grantmakers need concern themselves with. It was also federal GUIDELINES, which means there was flexibility.

This year’s is different. They are now federal REQUIREMENTS, which means there’s no flexibility. As was said previously, the 400 pages are not singularly devoted to being absolute shitheads to trans people. Theres a lot of stuff in there, some of which is the standard dry boring grants stuff, some of which is the horrible ideological warfare outlined above.

This document is issued by the OMB, the Office of Management and Budget, which is currently lead by fucking Russell Vought, the principal architect of Project 2025. This is how they’re going to implement all the horrible shit in there that wasn’t covered by Executive Order. Russell Vought is actively coming for my job, my marriage, and my kid, and most of my friends lost their jobs last year because of him. He is the fucking arch villain behind the heinous shit the current regime is doing.

So yes, please comment. You don’t have to read all 400 pages before doing so, it’s dry and dense as fuck, but I thought this information might be helpful. Also, while there is a public comment period, this isn’t voted on by Congress. The OMB just fucking issues it. Pressuring your elected officials into publicly saying “hey what the fuck are you doing here” is good, though.

mikkeneko

Please note the comment period is open through JULY 13th, not JUNE 13th. I saw a lot of relogs yesterday saying "last day!" and I just want to say it is very much not too late.

grison-in-space

As of today, 7/8/26, we have five days for public commentary on this to go through. I am begging y'all: if you care about independent science in the country that produces the most global science funding in the world, please leave a comment.

amber-tortoiseshell

"With genetic test results back from U.C. Davis Laboratories of toe-hair samples from each side of his body, I am excited to share that this sheep

🌟 IS INDEED a CHIMERA 🌟

His black mouflon side is a genetically different individual from his black gray side. The lab ran the test twice just to be sure!

Oh but wait, THERE IS MORE!

He is ALSO a she!

The black mouflon side is male.

The black gray side is female!

What I can tell you beyond these test results, is that this beautiful creature successfully bred four solid patterned ewes this winter that produced a total of 9 lambs, of which all were either solid pattern or mouflon pattern; 5 rams and 4 ewes. "

Source: Grand Valley Icelandics