people aren't even exaggerating indeed is literally like that. walmart attendant $13 an hour, target attendant $13 an hour, AI dick sucker $40 an hour, home depot attendant $13 an hour, guy who designs bullets that can only kill children $160k a year plus benefits, gas station manager $18 an hour
Is this about how ppl born in the late 20th century have a unique and fluid experience of navigating barriers to information access and its our responsibility to teach the younger folks how to tinker with technology to avoid being spoonfed everything we experience in order to have critical skills that keep us informed, autonomous, and able to hold power despite looming threats of authoritarianism or..........???
The pathologization of anger needs to be talked about. What do you mean my therapist is telling me that there’s something “chemically wrong” with me because I am still angry about my mom DYING OF COVID.
of course I’m still angry? My mom and 1.3 million other Americans are dead and you want me to shoot sunshine out of my ass about it?
“But It’s been 3 years since she died, you have complex grief” yeah and she was on a ventilator for 11 days and she kept writing “I am scared” and “I don’t want to die” on a notepad over and over again. While you were still going out unmasked and unvaccinated and coughing all over each other, I was living a nightmare I couldn’t fucking wake up from. And every single day I’m reminded of it in the form of “haha wasn’t the pandemic such a wacky time haha” and “I’m not getting a booster you can’t make me 🤪 (nobody asked)” and “it’s not real they made the numbers up!!!”
“You’re not coping” Ok here’s the deal; I’ll stop feeling this anger when we have a national memorial (we don’t) or a cdc equipped to stop it from happening again (we don’t) or a population that takes a deadly disease seriously BEFORE it effects them personally (WE DON’T!)
until then, I’m pretty sure my anger is A COMPLETELY NORMAL HUMAN REACTION given the facts at hand
the idea that every summer will be as hot if not hotter than this for the rest of my life is unbearable i need to (remembers suicide jokes are bad for my mental health) murder an oil executive
While I am fully on board with the "Everyone needs to interact with media other than stuff made for kids" but ngl some of y'all just see anything remotely colourful or joyful and assume it's for children
queer rep goes thru these cycles where every couple of years lgbt people are like "we get no rep in media and the representation we do get is way too sanitized and it feels so fake and flat. wheres the queer characters that are messy and flawed and REAL??"
then someone gets brave and makes a character who is a real bastard and makes all the wrong choices and is maybe even malicious at times and they make this character explicitly queer. and then fans are like "this is what you think of us?? worst representation ever" and the creator gets absolutely lambasted, ESPECIALLY if theyre queer themselves
then everyone else sees this and either thinks its too risky to include a queer character, or wants to make sure they're only doing the good and nice representation with no flaws or mistakes
then queer people are like "we get no rep in media and the representation we do get is way too sanitized and
the cognitive dissonance from people who want the products of modern medicine but get weird about animal research. like im sorry but this is necessary for the survival of the society we currently live in. and the scientists who work on these things are not evil cackling psychopaths. anyone you talk to in animal research has incredibly complex feelings about their work and incredibly complex relationships to the animals in their care. there are regulations and oversight and penalties in place to make the work as humane as possible and scientists are overwhelmingly the ones enforcing and advocating for better care.
@velvetdemon I'm doing a full reply because I want to give this question the time and space it deserves, and I really do appreciate your curiosity about this.
The short answer: It is deeply unethical. There are nowhere near enough willing patients in the world to be able to do this, and it would be criminal to put them through this.
The long answer: The one side of the equation you're focusing on is: how much of a drug is too much, to the point where it will cause negative side effects or even death? And this is crucial to know. But it's not just a matter of finding out the lethal dosage of a heart cholesterol medication, you need to know that it can actually lower the cholesterol of any living thing. There is no way to know this without giving it first to...a living thing.
But beyond this, I need to emphasize: The goal of a drug trial is to effectively cure people who are already suffering from disease, who are living on limited time.
Drug trials don't just happen on any member of the public, they need to happen specifically on people affected by the disease you're trying to treat. There is at any time a very limited and very marginalized population of the world affected by early onset, familial Parkinson's disease. Because you cannot ethically induce disease in a human being, you are working with, speaking with, and helping patients and their families who are hopeful and desperate for a cure.
If you were to jump straight to human trials from petri dishes, not knowing absolutely anything about how the drug functions in a living, breathing animal body, it would look like this:
We didn't know that minute quantities of the drug interact lethally with x, y, z medication that people are commonly also taking. X number of patients have died as a result.
We didn't know that the drug is fatal to people with [common variant] in their genetics. X more patients have died.
We didn't know the drug exacerbates x, y, z chronic illnesses. X number of people have acquired permanent, lifelong disabilities.
We didn't know the best way to deliver the drug, so we tried multiple ways: the people who received it intravenously are now suffering from a painful, costly, and debilitating condition that did not happen with the ingested form.
I could go on, and on, and on.
The vast majority of these problems can be nearly or almost entirely averted by testing other animals first.
These are all people who possibly could have waited for the normal progression from animal testing to human testing and thus received better outcomes. Some people will pass away in the time it takes to get to that point, and that's heartbreaking, and we all wish science could be faster.
But the cost of expediting science could mean a life of profoundly greater suffering or an even shorter life than the one where no intervention happens at all. And at that point, you have completely exhausted your trust, your goodwill, and your patients' hope, after you've failed to do anything or even worsened the lives of people who are already deeply suffering.
hi, i’m an animal research professional. making sure laboratory animals stay alive, healthy, and enriched has been my full-time job for several years now.
animal research is not the mad scientist wild west that PETA wants you to think it is. there are extremely strict federal laws in place to protect the well being of these animals. animal welfare organizations like AAALAC ensure that lab animals are treated with dignity & respect and are given enough specialized care & enrichment to be happy and content in captivity, just like AZA accreditation with zoos.
not a single animal from a zebrafish to a mouse to a dog to a macaque goes unaccounted for. if an animal gets moved to a new cage, paired for breeding, has a procedure performed on it, gives birth, gets sick or injured, dies, etc. it is legally required that this information is recorded and kept on file for the US federal government to access. failing to record & retain this information is very much punishable by US federal law.
let me tell you - if you abuse or kill an animal, even a mouse - you are almost certainly getting both fired & blacklisted from the industry. if you abuse or kill a more ‘advanced’ animal, such as a dog or monkey, you will likely face criminal charges. killing a monkey is as serious and disastrous as a nuclear meltdown. you are expected to reasonably explain every illness, injury, or death of an animal under your care. you must record all of this information. animals that are clearly suffering with low QOL are required to be euthanized according to AVMA guidelines.
research animals are highly expensive. yes, even the "lesser" animals like mice. the cheapest mice will run you a few hundred $ per individual, with some of the most expensive mice i've cared for being $25,000 per individual. in research we have the "three Rs" - reduction (reduce amount of necessary animals to a minimum), refinement (refine processes to ensure research is accurate and animals feel no pain or distress), and replacement (replace animals with non-living research models as they become available). i can assure you no proper research team is wasting animals (*do not* say "b-b-but elon musk--" his research team is actively being investigated for animal abuse by the government).
research methods that do not require live animals are currently being looked into & efforts spearheaded by - you guessed it - the animal research industry itself (notice how the animal rights people are strangely silent & unhelpful when it comes to this?) but current technology is rudimentary and does not compare to live animal models.
some research animal fun facts (US edition):
all species of animals are only allowed to have one single major surgery performed on them in their entire lifetime.
institutions with nonhuman primates must have a behavior program in place (run by knowledgeable primate specialists) to ensure that they are happy and receiving enough daily enrichment and social interaction.
institutions with dogs are required to have physical exercise programs in place. this means every individual dog gets a substantial amount of leashed AND free-roaming exercise daily, including playgroups with other dogs.
a majority of nonhuman primates get to retire to sanctuaries like peaceable primate sanctuary, and almost all dogs get retired and adopted out by organizations like homes for animal heroes. some institutions will also adopt out unneeded young rabbits, guinea pigs, rats, etc.
some strains of mice glow neon green (or orange or blue) under UV light. this is not harmful to them and is commonly seen in cancer research.
so yes, you can rest knowing that laboratory animals are treated with the utmost respect by their caretakers. and you can stop this awful, ignorant talk of human experimentation that will only end in the abuse of nonwhite people, LGBT people, disabled people, indigenous people, and so many others. please just take a look at this wikipedia page if you think “ethical” human experimentation can exist.
If you want to reduce animal testing - or at least, reduce the amount of things we need animals to be tested with - there is some growing traction in regards to mathematical modelling (also known as in silico studies), in vitro studies (i.e. test tubes), and 3D printing of organoids.
At the moment, this is not a substitute for animal testing. Bodies are incredibly complex and interconnected environments that we're still scratching our heads about, and animal testing is in a lot of ways the most efficient and least harmful way of testing things like medications.
If anyone wants to read more about these subjects, here are a few starting points (you will probably learn some new words, this is okay!):
Advances and Applications of Predictive Toxicology in Knowledge Discovery, Risk Assessment, and Drug Development research topic by the Frontiers in Pharmacology journal
Novel methods and technologies for the evaluation of drug outcomes and policies research topic by the Frontiers in Pharmacology journal
Spotlight on Artificial Intelligence in Experimental Pharmacology and Drug Discovery research topic by the Frontiers in Pharmacology journal
The Emerging Discipline of Quantitative Systems Pharmacology research topic by the Frontiers in Pharmacology journal
PDF Drug Combinations: Mathematical Modeling and Networking Methods by Vahideh Vakil and Wade Trappe
PDF Machine learning-based drug-drug interaction prediction: a critical review of models, limitations, and data challenges by Flaviu-Ioan Gheorghita et al.
PDF A review of 3D bioprinting for organoids by Zeqing Li et al.
3D Bioprinting for Engineering Organoids and Organ-on-a-Chip: Developments and Applications by Yuqing Ren, Congying Yuan, et al.
3D bioprinting of human iPSC-Derived kidney organoids using a low-cost, high-throughput customizable 3D bioprinting system by Jaemyung Shin, Hyunjae Chung, et al.
PDF Advancing organoid development with 3D bioprinting by Wenping Ma et al.
being single sucks [remembers that romantic love isnt the gleaming beacon of salvation that will fix the chasm within me] #mychasm #isupportmychasm [remembers not to trivialize my emotions] but it is painful to never have been deemed worthy of that kind of lasting love [remembers how many incels there are] but honestly you should be totally self-sufficient and never want anything ever [remembers that im evil] im evil
The goblin looked at the orc. The orc looked at the goblin. They both looked down at the crumpled shape of the Overlord, His Unholy Majesty, in his obsidian armor.
His final spasms had been mesmerizingly acrobatic. The fall down the steps leading up to his iron throne had pretzelled his body quite impressively, both arms folded behind his back and one leg bent at a jaunty angle.
The goblin looked at the orc. The orc looked at the goblin.
"Shit," said the goblin.
"Shit," said the orc.
"We're likely to get blamed for this," the goblin said. She walked over to the head of the glittering mangled heap and started pulling the helmet off.
"It's not our fault," the orc said. "It's hard to help someone choking when they wear two-hundred pounds of spiked armor at all times."
"Yeah, well," the goblin grunted. The helmet came free, and the bald head of the Overlord bounced on the stone with a hollow, coconut noise. "You know how it is in this bloody country - thieves get their heads cut off so they can't think about thieving, and all that." She fished in the Overlord's mouth with a finger and pulled out the obstructing olive on the end of her claw.
She popped it into her mouth and chewed. "What do you reckon they do for a regicide?" she said.
"We should run," the orc said. She had started bouncing her leg. "I hear that there's some places in the Alliance where they just kill you and let you stay dead. That's got to be nicer than what'll happen if we stay here."
The goblin started to nod - and then her gaze fell on the helmet.
It looked like a pineapple designed by a deranged blacksmith. It was all thorns and spikes and hard edges, as though the maker had been very determined to not let pigeons roost on it. The only bits that weren't solid iron were eyeholes. Nobody had ever seen the Overlord's face.
She held up the helmet and squinted from it to the orc. One of the thorns had been bent badly in the fall.
Nobody had ever seen the Overlord's face...
"Right," she muttered. "Right. Could work - or."
The orc had a sudden vision of the immediate future. "No," she said.
"I mean you're about his height-"
"No."
"It would just be for a-"
"Absolutely not."
"Just hear me out," the goblin said. "Outside of this room are two-thousand men and orcs and goblins who are absolutely gonzo about this man, and there's a whole country of them outside of the castle, and at any moment someone's going to walk in that door and see one dead tit in black armor and two unbelievably dead idiots next to him.
"Or." She tossed the helmet up like a basketball to the orc, who fumbled and tried to find somewhere to hold it that wasn't a knife's edge. "We chuck him out the window now, walk out the door in the armor, and ditch the armor as soon as nobody sees us."
The orc had started bouncing her leg again. "They'll know something's up the second I walk out of the room."
"No worries," said the goblin. "Leave that to me."
---
It had been a very strange year for the Empire.
Change had rolled across the land as slow and inevitable as a glacier. Roads and bridges carved the gray, blasted wildlands, and a number of social reforms had made the country a place where you could be miserable, yes, but miserable in comfort and safety, and that was an improvement.
Barely anyone got boiled alive in molten metal, and even if the disgusted sun never rose to light the Empire, at least you had a roof over your head to protect yourself from the acid rain.
"Your empire flourishes, Your Unholy Majesty," the magician said over her wine glass. She looked down from the tower's balcony over the gleaming stone battlements. Some work had been done to line the castle and surrounding city with sizzling, crackling alchemical lights at night. The whole thing glowed like something dangerously radioactive.
The suit of armor waved a languid, glittering gauntlet over to the goblin, who bowed.
"His Abominable Gloriousness Thanks You," the goblin recited. "The Prosperity Of His Empire Can Only Be Achieved Through The Prosperity Of His People."
"If I may be so bold, I am quite pleased that you had chosen to take my counsel under consideration," said the magician. "We have accomplished many things together."
Another wave. Another bow. "The Overlord, May His Presence Swallow The Sun And Stars, Thanks You As Well."
"It was quite gratifying to see you change your mind, after so many centuries of denial." The wine was swirled. "Tell me, what was it that finally gave you cause to listen to me?"
There was the slightest hesitation. The goblin's eyes flicked to the armor, then to the magician. She puffed out her chest. "Do you question the wisdom of His Austere Lugubriousness?" she asked.
The magician looked at the goblin. She looked at the armor. She tipped her head back and drank the wine too quickly.
She looked back at the armor. "I know you're the orc, you moron," she said.
The room went deathly still. An alchemical light fizzled.
The orc pulled off the helmet, sending long, untied hair down tangling, and said: "How could you possibly-"
"Because you're both idiots!" the magician said. The goblin jumped. The orc jumped with a noise like a dropped stove. "What kind of a plan was this?! If it wasn't for me, you would have been turned into fertilizer months ago."
She closed her eyes. She took a long, dramatic breath. She set the wine glass down on the balcony rail.
"How did the Overlord die?" she asked when she seemed like she had gotten a hold over herself.
"Choked on an olive," said the goblin.
"Threw his body out the window," said the orc.
"You don't have to mention the window," said the goblin.
"Right," said the orc. "Sorry."
The magician looked out over the city, hand curled thoughtfully under her nose. "Who knows about this?"
"Just us. And, uh. You. Apparently."
"And why did you accept my counsel?"
The orc blinked. "Sorry?"
"Why did you accept my counsel?" the magician repeated.
"Well," the orc said. "Well - you seemed like you had good ideas-"
"Great ideas!" the goblin said with an edge of desperation. "Don't know why the old bastard didn't listen to you!"
"Right - right," said the orc. "And when we figured we were stuck doing this - well, it just made sense, really."
The magician seemed to absorb this. She nodded. "All right," she said, striding between the two and grabbing the crystal decanter.
"Um," said the orc. "Sorry. What happens now?"
"What happens is that you two will continue to serve as Overlord," said the magician. "You will continue to take my counsel. We will continue to reform this bloody country, and gods willing, we will turn it into the crown jewel of the world by next Midwinter."
The orc looked at the goblin. The goblin looked at the orc.
"Really?" the goblin asked.
"Oh yes," said the magician. "I've worked hard to be counsel to the Overlord, and I have no reason to stop now. And besides-"
She looked the orc up and down with a deliberate slowness, poring over every microscopic detail, eyes tracing over every jagged line, and grinned like a panther.
"You look much better in the armor than he ever did," she said. Dark robes swirled like a becleavaged thundercloud, and she strode out through the high iron doors, decanter in hand.
The goblin looked at the orc. The orc looked at the goblin.
why is there an upgrade button on gmail. why does twitter want me to scan my palm to get into my account. why is google a chatbot. why does the transit app make a transit app wrapped for me. why does youtube keep shoving its infinitely scrollable shortform content down my throat. why do my doctor and psychiatrist and therapist want to use an ai notetaker during our appointments. why do free trials want my credit card number. why are most scholarship websites just data brokers. how do i make capitalone stop sending me mail. why is my school making its own special chat gpt powered chatbot. why is every third video on instagram an undisclosed ad. why is nothing online real anymore. why is everything so FUCKING STUPID
actually I think you should be normal about ordinary citizens of authoritarian countries and yes that applies even to that country you're thinking of right now
please read this even if you're not indian. especially if you're not indian.
you've seen the jokes. india is "dirty", indians are "everywhere", why don't they fix their own country. ok. let me tell you why, and what's happening right now while nobody's watching.
first, the history you skipped: britain ruled india for two centuries and drained it. economist utsa patnaik's research estimates around $45 trillion in today's money was taken. the india that got independence in 1947 was one of the poorest countries on earth. every "why is india like this" question starts there. you don't get to profit off a robbery and then mock the crime scene.
now, what's happening RIGHT NOW:
in may the question paper for NEET leaked. that's the national medical entrance exam. over 2.2 million students took it. cancelled. years of studying, families' savings poured into coaching, gone overnight because someone sold the paper. students died by suicide after. these were kids who wanted to be doctors.
and out of that came a protest movement. a gen z group called the cockroach janta party, started by a 30 year old named abhijeet dipke, got 22 million instagram followers within DAYS. they've been doing a sit-in at jantar mantar in delhi demanding education minister dharmendra pradhan resign.
and then there's sonam wangchuk. if you've watched 3 idiots, he's the real engineer the character was based on. built solar schools in ladakh. invented ice stupas so himalayan villages have water. spent his whole life on education. he's 59 and he's been on hunger strike for 17+ days now. reporters went to see him this week and he was too weak to talk. and the troll armies are calling him "anti national" and "foreign funded". a man starving himself for other people's children. that's the thing here, anyone who asks a question is suddenly a traitor.
it's not one incident, it's everywhere you look:
• infrastructure worth thousands of crores failing within months of the ribbon cutting. tunnels collapsing in regions where heavy rain is a guarantee, not a surprise.
• youth unemployment near 10% for ages 15 to 29, 13.6% in cities. in a country of 1.42 billion where more than half the population is young.
• only about the top 3% of indians earn above 10 lakh a year. meanwhile billionaire wealth keeps ballooning and the headlines celebrate it.
• manipur burned for over two years. an ethnic conflict, tens of thousands displaced, and the prime minister barely said the word manipur while it happened.
• journalists raided. critics' houses bulldozed. activists sitting in jail for years without trial under laws like UAPA. our press freedom ranking has cratered.
• even the petrol is a fight now, ethanol blending pushed through while drivers complain about their engines and get no straight answers.
and through all of it, the PM, who came to power on religious polarisation (americans, sound familiar?), travels abroad for photo ops and has not held one single open press conference in over a decade. not one.
what i'm asking:
if you're not indian: share this. our media mostly won't cover any of it because the big outlets are owned by the same billionaires the government serves. the only reason wangchuk's fast is getting any coverage is people refusing to look away.
if you ARE indian: speak up even if you're comfortable. especially if you're comfortable. join the protests. add to this, correct me, translate it. staying quiet is a choice when nothing in this post touches your life.
india is not "dirty". india was robbed, and it's being robbed again, from the inside this time. but it's also the country where a 59 year old will starve for strangers' kids and 22 million young people will rally behind a party literally named after cockroaches, because cockroaches survive everything.
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