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Cytarabine
In this article, we will discuss Cytarabine (Clinical Pharmacology). So, let’s get started. Clinical Pharmacology Cell Culture Studies Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G1…
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Reposted from @molecule_of_the_day (@get_regrann) - Cytarabine, also known as cytarabine arabinoside (ara-C) and sold under the trade name Cytosar-U, is a chemotherapy medication 💊 used to treat various forms of leukemia (blood cancer). These include acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. Cytarabine also possesses antiviral 🦠 activity, and it has been used for the treatment of generalised herpesvirus infection. However, the major side effects of cytarabine are bone 🦴 marrow suppression and brain toxicity, making cytarabine not the most suitable choice as an antiviral drug. To prevent 🚫 the side effects and improve the therapeutic efficiency, various derivatives of these drugs (including amino acid, peptide, fatty acid and phosphates) have been evaluated, as well as different delivery systems. Thanks 🙏 anonymous for the suggestion! The molecular structure was created using ChemDoodle. Be sure to follow them at @ichemlabs! #cytarabine #arac #cancer #chemotherapy #leukemia #bloodcancer #disease #medicine #drug #health #wellness #antiviral #bonemarrow #photooftheday #chemistry #art #molecule - #regrann (en Time Traveler Technologies Ltd.) https://www.instagram.com/p/B3WEaefF7cd/?igshid=1wxmd0iab51xs
Cytarabine | Find why Cytarabine is prescribed including its typical usage, side effects, and safety, interactions, warnings and ask a doctor for expert advise on Cytarabine at MediKlik.com
Cytarabine | Find why Cytarabine is prescribed including its typical usage, side effects, and safety, interactions, warnings and ask a doctor for expert advise on Cytarabine at MediKlik.com
𝄢 DOO DOO DOO DOO! ♪
シタラビン (Cytarabine) とは、抗悪性腫瘍剤(抗がん剤)の一種。商品名はキロサイド(Cylocide)。Ara-CまたはAraCという略号で表されることがある。核酸の誘導体である。 【作用機序】 DNAの合成過程において、CDPレダクターゼおよびDNAポリメラーゼを阻害する。また、白血病細胞の分化を誘導する[1]。 【効能・効果】 ■急性白血病(赤白血病、慢性骨髄性白血病の急性転化例を含む)。 ■消化器癌(胃癌、胆嚢癌、胆道癌、膵癌、肝癌、結腸癌、直腸癌等)、肺癌、乳癌、女性性器癌(子宮癌、卵巣癌等)等。 ただし他の抗腫瘍剤と併用する場合に限る。 ■膀胱腫瘍 ■シタラビン大量療法(相当のリスクのある治療法) ・再発又は難治性の下記疾患 ・急性白血病(急性骨髄性白血病、急性リンパ性白血病) ・悪性リンパ腫 ・ただし、急性リンパ性白血病及び悪性リンパ腫については他の抗腫瘍剤と併用する場合に限る。 上記のように効能・効果は多数あるが、実際には血液がん中心に使われる。 【副作用】 骨髄抑制、ショック、シタラビン症候群、急性呼吸窮迫症候群、間質性肺炎、高ビリルビン血症を伴う肝障害、不整脈、心不全、消化管潰瘍や出血や好中球減少性腸炎等の消化管障害、可逆的な言語障害や運動失調や傾眠や昏睡や白質脳症等の中枢神経系障害、肝膿瘍、急性膵炎、肺浮腫、有痛性紅斑、脱毛(症)、発疹、頭痛、活動低下、傾眠、言語障害、食欲不振、嘔気、嘔吐、下痢、ALT (GPT) 上昇、AST (GOT) 上昇、LDH上昇、ビリルビン上昇、肝機能異常、Al-P上昇、γ-GTP上昇、電解質異常、血中尿酸上昇・低下、電解質代謝異常、フィブリノーゲン増加、凝固時間延長・短縮、FDP増加、BUN上昇・低下、尿糖陽性、クレアチニン上昇、尿蛋白陽性、低蛋白血症、結膜炎、体重増加・減少、CK上昇・低下、感染、敗血症、ウロビリノーゲン陽性など多数ある。
https://ja.wikipedia.org/wiki/シタラビン
Ending the B cycle
A just finished a B cycle with methotrexate and cytarabine so we're waiting for the blood transfusions and mouth sores that seem to characterize our experience with these drugs. He also has a sinus infection and RSV. The respiratory infection freaks me out a little bit because I've read too many blogs where that sort of thing led to ICU visits and in one case caused the death of a little girl. But, I'm trying not to think about that and to just focus on pumping A full of antioxidants, food, fluids, and rest. Maybe he can kick this before his counts completely bottom out?
The good news is that he is still eating some. Tonight we made runzas. They're really simple, you take those triangle rolls from the grocery store and fill them with cooked ground beef, with a little bit of onions, chopped carrots and chopped celery and then cook then in the oven. They were pretty easy to eat for A, soft and also gave him some good protein. Then I made some cheesy cauliflower and a fruit salad. He managed to eat everything. We'll see when the mouth sores start and then it's on to a completely new set of recipes, some from this awesome book from the National Cancer Institute (http://www.cancer.gov/cancertopics/coping/eatinghints/page1), which I requested and they sent to us for free - - so so helpful and wonderful!
What chemo-induced conjunctivitis feels like