May 23, 2023
WHO IS ROBERT W MALONE?
seen from Germany
seen from Brazil
seen from Brazil
seen from Brazil
seen from Brazil
seen from South Korea
seen from Brazil
seen from Brazil
seen from Brazil
seen from Hong Kong SAR China
seen from China
seen from Malaysia
seen from France
seen from Indonesia
seen from China
seen from Malaysia
seen from Canada
seen from T1
seen from Malaysia
seen from France
WHO IS ROBERT W MALONE?
Zantac recall means my throat is fucked and I can't breath right while lying down; need to ask GP to call in a prescription for Pepcid or Tagamet or something.
In lab tests, an antacid didn’t prevent coronavirus infection, but clinical tests are needed to see if it can help people who already have COVID-19.
An over-the-counter heartburn remedy probably won’t directly stop coronavirus infections, a new study suggests.
Anecdotal reports from China suggested people hospitalized with COVID-19 who were taking famotidine (sold under the brand name Pepcid) had better outcomes than people who took a different type of antacid called a proton pump inhibitor. But famotidine has no direct antiviral activity against SARS-CoV-2, the virus that causes COVID-19, according to preliminary results reported July 15 at bioRxiv.org.
Those findings, which have not been reviewed by other scientists yet, suggest famotidine won’t help prevent coronavirus infections or illness. But they don’t rule out that the drug might help in other ways, says Mohsan Saeed, a virologist at Boston University School of Medicine. “We’re not challenging that famotidine might help,” he says. “We’re saying that the mechanism of action is not antiviral.”
he result isn’t a complete surprise. “A compound of this nature having any role in infectious disease is kind of a head-scratcher,” Saeed says. But a couple pieces of evidence had hinted that it might help against the virus.
Besides the reports out of China, two studies using computer simulations of coronavirus proteins predicted that famotidine might dock with and inhibit important viral enzymes called proteases that help the virus replicate. Based on those findings, Northwell Health in the New York City area began a clinical trial to test the antacid against the coronavirus in people.
“We were kind of surprised, because there is no laboratory evidence to show that this compound might have some effect,” Saeed says.
The data that originally suggested benefits from famotidine aren’t strong enough to justify basing treatments on the drug, says Tobias Janowitz, an oncologist and biomedical scientist at Cold Spring Harbor Laboratory in New York, who was not involved in the study. “Everything that has been published so far cannot be considered evidence for clinical efficacy,” he says. That includes a small study Janowitz was involved in which also found hints that over-the-counter Pepcid might improve symptoms for some people diagnosed with COVID-19.
Sign up for e-mail updates on the latest coronavirus news and research
Just “because a statistical association exists in these anecdotal reports doesn’t mean it is actually doing anything,” Shmuel Shoham, an infectious disease specialist at Johns Hopkins Medicine said June 26 during a news conference announcing the Infectious Diseases Society of America’s revised treatment guidelines. The infectious disease society doesn’t recommend taking famotidine as a coronavirus treatment outside of a clinical trial.
To test famotidine’s antiviral activity, Saeed teamed up with Ali Munawar, cofounder and chief executive of Boston-based Bisect Therapeutics, Inc. Munawar’s lab did two different biochemical analyses to test whether Pepcid can bind to viral proteases as the computer simulations had predicted. Neither test showed any sign of binding.
But it was still possible that the antacid might work in other ways against the protease enzyme. So the team conducted separate analyses of enzyme activity which found no protease inhibition at all.
The team also tested whether famotidine could stop the coronavirus from infecting monkey cells or human lung cells grown in lab dishes. “We did not see any effect on viral infection,” Saeed says. By comparison, the antiviral drug remdesivir “nicely inhibited viral replication,” he says (SN: 7/13/20).
While the work has not yet been vetted by other scientists for publication in a scientific journal, the results are in line with unpublished findings from Janowitz’s Cold Spring Harbor colleagues Leemor Joshua-Tor and Nicholas Tonks who found that famotidine doesn’t inhibit the proteases as predicted, he says.
Researchers say there is still a chance that famotidine might help slow the hyperactive immune system reactions known as cytokine storms, which do damage in some severely ill COVID-19 patients (SN: 7/2/20).
“We’re not shutting the door on this being an effective therapy,” Shoham said, but doctors should not prescribe the drug to treat COVID-19 and people should not take over-the-counter Pepcid as a coronavirus remedy. The antacid needs further study in randomized clinical trials, he said. Janowitz and colleagues are planning just such a trial.
Today was a blast. Revived #pepcid #solumedrol and a #breathingtreatment scripts for the absolute medication #prednisone and a rescue inhaler since my is at my house. Feeling like absolute shit. #immunology appointment tomorrow to see if she wants to change anything. #chronicillness #mcas #mcad #xolair #allergicreaction #anaphylaxis #selfie #selfies #potd #picoftheday #hospital #chronicpain
SO MANY RL CRAIGS
University of Florida Connections Abound With Ukrainian Alchem Scientists
:::
—Repost from 2020:
Michael Callahan's career began in USAID and in the bioweapons labs of the former Soviet Union, advancing the agenda of the global...
Joe rogan interviews the mRNA medicine “inventor” recently banned from twitter and LinkedIn
https://open.spotify.com/episode/3SCsueX2bZdbEzRtKOCEyT?si=46DHvF9RSGua8g96aWrA1A
Note: the twitter ban was super convenient timing to generate more viewers for the algorithm
:::
-Odd that he claims he got it twice. Most old school (pmrior to 2020) virologists would say that’s impossible. Is he sending a message for people to look into his Feb 2020 infection?
-he claims Pepcid does work, in fact he used it to cure himself in February 2020.
:::
May 2020:
Famotidine, best known as the active ingredient in the heartburn drug Pepcid, is being studied in hospitalized COVID-19 patients at Northwel
https://www.wanderwoodsandwater.com/post/617678271509938176/a-heartburn-drug-for-covid-19-all-about-an
August 2020:
Michael Callahan's career began in USAID and in the bioweapons labs of the former Soviet Union, advancing the agenda of the global...
https://www.wanderwoodsandwater.com/post/625357786636828672/darpas-man-in-wuhan