Medical Art
- by LyonRoadArt (Kaitlin Walsh)

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Medical Art
- by LyonRoadArt (Kaitlin Walsh)
The neurons that rewrite traumatic memories
Memories of traumatic experiences can lead to mental health issues such as post-traumatic stress disorder (PTSD), which can destroy a person’s life. It is currently estimated that almost a third of all people will suffer from fear- or stress-related disorders at one point in their lives.
Now, a new study shows – at the cellular level – how therapy can treat even long-term memories of trauma. “Our findings shed, for the first time, light onto the processes that underlie the successful treatment of traumatic memories,” says EPFL Professor Johannes Gräff of EPFL’s School of Life Sciences, whose lab carried out the study.
In the field of treating traumatic memories there has been a long-debated question of whether fear attenuation involves the suppression of the original memory trace of fear by a new memory trace of safety or the rewriting of the original fear trace towards safety. Part of the debate has to do with the fact that we still don’t understand exactly how neurons store memories in general. Although they don’t exclude suppression, the findings from this study show for the first time the importance of rewriting in treating traumatic memories.
Research in this area focuses on understanding the brain’s capacity to reduce traumatic memories, but surprisingly few studies have investigated treatment options for attenuating long-lasting trauma (aka “remote fear”) in animal models.
The EPFL scientists found that remote fear attenuation in the brain is connected to the activity of the same group of neurons that are also involved in storing these memories. Working with mice, the scientists have located these neurons in the brain’s dentate gyrus, an area of the hippocampus that is involved in the encoding, recall, and the reduction of fear.
The mice used in the study are genetically modified to carry a “reporter” gene that produces an identifiable and measurable signal, e.g. a fluorescent protein, following neuronal activity. Using a fear-training exercise that produces long-lasting traumatic memories, the scientists first identified the subpopulation of neurons in the dentate gyrus that are involved in storing long-term traumatic memories.
The mice then underwent fear-reducing training, which resembles exposure-based therapy in humans – the most efficient form of trauma therapy in humans today. Surprisingly, when the researchers looked again into the brain of the mice, some of the neurons active at recalling the traumatic memories were still active when the animals no longer showed fear. Importantly, the less the mice were scared, the more cells became reactivated. This was a first hint that the same population of neurons may be involved in storing and attenuating traumatic memories.
The researchers then reduced the excitability of the recall neurons during the exposure therapy and found that the mice showed poorer fear reduction compared to controls. But when they reduced the excitability of other neurons in the dentate gyrus, there was no such effect, showing that the recall neurons in the dentate gyrus are crucial for fear attenuation.
Finally, when the researchers enhanced the excitability of these recall neurons during the therapeutic intervention, they found that the mice showed improved fear reduction. Thus, they concluded that attenuating remote fear memories depends on the continued activity of the neurons they identified in the dentate gyrus.
Anna Wintour (Now I Feel In Love) by Azealia Banks, 2018 (Dir. Matt Sukkar)
siri read a message from my mom (2017)
i think we’ve gotten as close to a real life Howler as we can get
this is literally the funniest thing Ive ever seen in my life
Would you kindly give me a run-down on executive dysfunction? There is no reliable resources in my mother tongue and I question if my "I decide to go shower but don't" and "I decide to sleep but don't" qualify despite me being on my mobile instead of doing what I set my mind on and what I WANT to do. I'm often tired and want to sleep but instead keep chatting with people or browsing tumblr.
Hey anon,
Thanks for your question! Executive dysfunction means that your brain doesn’t do executive functions quite right. Some executive functions include:
planning
organization
monitoring performance
self-awareness
multi-tasking
problem solving
learning rules and social behavior
motivation
controlling your emotions
concentrating
taking in information
So that’s a lot of stuff. Sounds like it effects basically everything, right? Well, like a lot of mental health/psychiatric symptoms, executive dysfunction affects everyone differently and presents everyone different challenges.
This website is focused on brain injuries, but it has a lot of good information and a run down on how executive dysfunction can manifest itself in relation to each of the executive functions.
What you describe as “I want to shower but don’t” could definitely be due to executive dysfunction. Executive dysfunction often causes issues with initiating activities (like getting up to go shower) and organizing activities (figuring out what you need to have a shower, and doing it).
More executive dysfunction resources:
one person’s description of how their executive dysfunction has affected their life and common symptoms
how executive dysfunction can affect school
executive dysfunction and ADHD
some tips to deal with executive dysfunction
good post explains a bunch of stuff about executive dysfunction
cool metaphor explaining what executive dysfunction is like
If you think you’re having issues with executive dysfunction, I strongly suggest you talk to a therapist or other mental health professional. They can help you figure out exactly what’s going on and strategies for how to deal with executive dysfunction if that’s what you’re struggling with.
~mod Gwyn
autistic + ND youtubers:
Amythest Schaber / @neurowonderful / informational videos about autism (ask an autistic)
invisible I / chronic illness and autism informational videos + vlogs (including sensory DIYS and hauls)
princessaspien / autism videos and music vlogs
minty frills / fashion and autism videos
megan Rhiannon / @baby-gloom / vlogs, autism, journalling and university
Ashton Daniel / ND experiences, stim toys, vlogs + trans resources
how to ADHD / adhd resources and informational videos + stim toys
Barry Aldridge / doctor who / special interests
IndieAndie / music, autism and vlogs
bonus video with cool auties
feel free to add your own!
Hi. I work in a research setting and I often see autistic children of elementary-school age. Sometimes I have kids who are difficult to manage because they appear to be having tantrums/meltdowns. But being a NT with no prior experience with autistic children, I find it difficult to distinguish between behavior that stems from them being autistic and wanting to adjust their environment to make it less uncomfortable, and behavior that might just be a six year old acting out (e.g yelling words 1/2
/phrases over and over, pushing chairs around without concern for surroundings, throwing assessment materials, etc.). I’m often at a loss as to whether or not the behavior needs reprimanding, and I wonder if I’m doing wrong as the adult by keeping silent, ignoring the behavior and assuming they need to ‘act out’ in this way to reduce anxiety. I want to be sensitive to their needs but still be in control of the situation as the adult. Can you please advise me? Thanks 2/2
The first, and hardest, thing to do is make sure that you understand the difference between a tantrum and a meltdown. In the most simple terms, tantrums are about things that a child wants. Meltdowns are about things that a child needs. The differences may seem subtle at first, but when you know what to look for they are usually fairly easy to differentiate.
Tantrums (are about wants)
Goal Oriented
The person has a specific goal in mind.
Examples: I want pizza. I want to play. I want that toy. I don’t want to do my homework. I don’t want to clean my room.
About Control
Is intentionally trying to manipulate the situation to what they believe is a favorable outcome.
They are in control of their actions.
Performed for Audience
A tantrum is directed at authority figures that can give the person what they want; teacher, parent, etc.
Will last until they get what they want.
Monitors Engagement
They make sure that their audience is watching / listening, and will adapt if they are not.
Example: If they are throwing things and the authority figure looks away, the person might start screaming. If the authority figure leaves, the person might follow.
Monitors Environment
The person having the temper tantrum monitors the environment to prevent themselves from being hurt.
They will avoid injury, and if they are hurt will likely react to the injury even to the exclusion of their goal.
Escalate / Deescalate Quickly
When a person decides to throw a temper tantrum, there is usually a very swift escalation.
There may be an explicit threat such as, “give me what I want or I will scream.”
When the goal is achieved, deescalates very quickly.
Some Signs of a Tantrum
Wants something
Want is usually easily achievable
Access to want is denied by another
Example: An authority figure saying they cannot play
Example: Another child refusing to share a toy
May be threat of tantrum
Example: If you don’t X, I will Y
Meltdowns (are about needs)
Not Goal Oriented
May not know what they need.
Usually the result of overstimulation
Loss of Control
Fight or Flight Response.
May not respond at all to stimuli outside of meltdown.
May not end immediately when source stimuli removed.
Not Performative
Usually directed at self.
Will last at least until offending stimulus is resolved
Does not Monitor Engagement / Environment
Will not seek engagement.
May engage if forced to.
May react violently to forced engagement.
May engage in self injurious behaviors.
Likely unaware of surrounding dangers.
Escalation Varies / Deescalate Slowly
Escalation may be fast.
Example: Sudden nose like fire alarm.
Escalation may be slow.
Example: Bothersome tag in clothing.
Deescalation is usually slow.
Removal of or from stimuli may not trigger deescalation initially.
Meltdown may be self-supporting trigger of meltdown
Recovery usually takes time
Some Signs of Meltdowns
Change in engagement.
Example: Staring at nothing.
Change in behavior.
Example: Rocking, fidgeting, or otherwise stimming
Expresses unrealistic needs
May be nonspecific
Example: Vague request to make it stop.
May be unattainable
Example: Stop it from raining.
Expresses fear of stimuli.
Expresses pain from stimuli.
May be counterintuitive
Example: A soft repetitive hum from a fan that is “painful” to hear, causes a headache or stomachache, makes their skin crawl.
Triggers signs of mental illnesses or other neurological states.
May appear as part of slow or quick escalation
Body Focused Repetitive Behaviors.
Obsessions / Compulsions.
Tics.
Impulsive behaviors.
Malaise.
Worry or fretting.
Other general signs of depression or anxiety.
Tantrums are usually expected in the age range of about 2 to 6 years old, but as autistics are developmentally disabled, it is possible for this to extend to any age, depending on the specific autistic.
To complicate it more, in some autistics expressing extremes of emotion is in and of itself a meltdown trigger. Something that begins as a tantrum can become a meltdown for a variety of reasons, though I would say this isn’t too incredibly common unless the autistic in question has emotionally triggered meltdowns over other emotions as well.
So yeah. That’s a lot of information there, I’m sure. Hopefully this breakdown will help! If you have any more questions please feel free to send me another ask.
I work in a childcare and know some coworkers and parents who don't know a lot about autism. Do you know of any really good articles/websites I could show them?
Our resources page has a lot of great information about autism on a variety of topics. The following are some of our intro to autism resources:
What is Autism?
Another What is Autism?
What is Autism? (ASAN)
What is Autism? In Plain Language
Dictionary of Autism-related Concepts
Inclusive Autistic Traits
Myths About Autism
Autism FAQ
ASAN’s About Autism
Ask an Autistic (videos about autism by an autistic)
Don’t Mourn For Us
Autism Resources
Autism Masterpost
Autism 101
-Sabrina
autistic + ND youtubers:
Amythest Schaber / @neurowonderful / informational videos about autism (ask an autistic)
invisible I / chronic illness and autism informational videos + vlogs (including sensory DIYS and hauls)
princessaspien / autism videos and music vlogs
minty frills / fashion and autism videos
megan Rhiannon / @baby-gloom / vlogs, autism, journalling and university
Ashton Daniel / ND experiences, stim toys, vlogs + trans resources
how to ADHD / adhd resources and informational videos + stim toys
Barry Aldridge / doctor who / special interests
IndieAndie / music, autism and vlogs
bonus video with cool auties
feel free to add your own!
coconut water is fucking gross
STILL NASTY
op just say u hate brown ppl and go 😔
I hate brown ppl *goes*
YALL KEEP TALKING ABOUT “OH IT’S GOOD STRAIGHT FROM THE SOURCE” WRONG. IT’S NASTY IN ANYWHERE
white people ruined coconut water the same way they're going to ruin nopales. Goya Aguas de Coco are delicious and refreshing.
been feeling a little lost, unmotivated, and down lately. but seeing this reminds me to remember that, in the end, it’s my life and no one can help me but myself. hope this brings some motivation to all of you as the semester is coming to an end 💕
Airfordable, a Chicago-based, black-owned startup, is making it easier to afford flights so that you can go on a trip without having to pay a huge lump sum.
The startup allows you to pay for your trip in more affordable installments by submitted a picture of your itinerary and travel plans, and after an initial deposit, you can make payments up to your departure date.
Cofounder and CEO Ama Marfo, a Ghana native, said that she was inspired to create the startup while she was attending Drexel University in Philadelphia.
“We have a lot of students using Airfordable to travel home or for study abroad programs. While other users are planning travel based around life milestones such as destination weddings and family vacations. We are covering just about any travel need you can think of,” Marfo said.
source
Flying is expensive… Seems like a great idea for college students. This can be a good service for people with bad credit and want to travel. The fees might be high, but travel might be the one thing that is worth it. I hope it succeeds.
Black buying power will reach $1.3 trillion in the next few years, I hope that money will be spent at black-owned businesses.
#BlackBusiness #BlackUnite
this just confirmed that 2017 goals will be accomplished
Shit! I really needed this. We pay for flights several times a year for my stepdaughter to visit us.
@awkblqckguy
@chuletasss
For your next trip
I got comfortable and I started confiding my feelings in him. He didn't realize how fucked up my negative thought patterns are, that I'm not just "sad&quirky", I'm actually stunted and ill. And I'm pretty sure he's annoyed and over it. I feel dumb and gross.