Alchemists, you were right. It is magic.

A sideblog to talk about things I'm studying and general science stuff. Main is @armillaryspheres

[macgyvermedical]

When Drugs Became Available

Have you ever been writing some historical fiction and wondered "hey, I wonder if my characters would have been able to pop an ibuprofen in 1977?" Well, you're in luck, because this post is all about when common medications became available:

Acetaminophen: 1950

Albuterol: 1969 (UK) 1982 (US)

Allopurinol: 1966

Alprazolam: 1981

Amitriptyline: 1961

Amlodipine: 1990

Amoxicilin: 1972

Amphetamine/Dextroamphetamine (together as Adderall): 1996

Apixiban: 2012

Aripiprazole: 2002

Aspirin (first NSAID): 1899

Azidothymidine (first antiviral): 1987

Barbital (first barbiturate): 1903

Bupropion: 1985

Buspirone: 1986

Calcium Carbonate (TUMS): 1930

Captopril (first ACE inhibitor): 1981

Chlordiazepoxide (first benzodiazepine): 1960

Chlorothiazide (first thiazide diuretic): 1957

Chlorpromazine (first antipsychotic): 1952

Cyclobenzeprine: 1977

Diphenhydramine: 1946

Furosemide: 1959

Fluoxetine (first SSRI): 1988

Gabapentin: 1993

Glipizide: 1984

Hydrochlorothiazide: 1959

Ibuprofen: 1969 (UK) 1974 (US)

Insulin: 1923 (though many types of insulins would become available over the next century)

Imipramine (first tricyclic antidepressant): 1959

Iproniazid (first antidepressant (MAOI)): 1952

Levothyroxine: 1927 (though desiccated pork thyroid was used for the same reasons as early as 1890)

Lisinopril: 1987

Lithium: 1949

Losartan (first ARB): 1995

Lovastatin (first statin): 1987

Naproxen: 1976 (Rx) 1990 (OTC)

Nitrogen Mustard (first chemotherapy agent): early 1940's

Methotrexate: 1947

Methylphenidate: 1954

Metformin: 1957 (France) 1995 (US)

Metoprolol: 1978

Montelukast: 1998

Morphine: early 1800's

Omeprazole: 1989

Penicillin: 1945

Phenbezamine (first antihistamine): 1942

Prednisone: 1955

Propranolol (first beta blocker): 1965 (UK) 1967 (US)

Sertraline: 1990

Spironolactone: 1959

Sulfanilamide (first modern antibiotic): 1935

Tolbutamide (first oral anti-diabetic drug): 1956

Tramadol: 1977 (Germany) 1995 (US)

Trazodone: 1981

Valacyclovir: 1995

Verapamil (first calcium channel blocker): 1964

Warfarin: 1954

Zopiclone (first "Z-drug"): 1986

[macgyvermedical]

Someone asked for this list in date order, so here it is!

Morphine: early 1800's

Aspirin (first NSAID): 1899

Barbital (first barbiturate): 1903

Insulin: 1923 (though many types of insulins would become available over the next century)

Levothyroxine: 1927 (though desiccated pork thyroid was used for the same reasons as early as 1890)

Calcium Carbonate (TUMS): 1930

Sulfanilamide (first modern antibiotic): 1935

Nitrogen Mustard (first chemotherapy agent): early 1940's

Phenbezamine (first antihistamine): 1942

Penicillin: 1945

Diphenhydramine: 1946

Methotrexate: 1947

Lithium: 1949

Acetaminophen: 1950

Chlorpromazine (first antipsychotic): 1952

Iproniazid (first antidepressant (MAOI)): 1952

Methylphenidate: 1954

Warfarin: 1954

Prednisone: 1955

Tolbutamide (first oral anti-diabetic drug): 1956

Chlorothiazide (first thiazide diuretic): 1957

Metformin: 1957 (France) 1995 (US)

Furosemide: 1959

Hydrochlorothiazide: 1959

Spironolactone: 1959

Imipramine (first tricyclic antidepressant): 1959

Chlordiazepoxide (first benzodiazepine): 1960

Amitriptyline: 1961

Verapamil (first calcium channel blocker): 1964

Propranolol (first beta blocker): 1965 (UK) 1967 (US)

Allopurinol: 1966

Albuterol: 1969 (UK) 1982 (US)

Ibuprofen: 1969 (UK) 1974 (US)

Amoxicilin: 1972

Naproxen: 1976 (Rx) 1990 (OTC)

Cyclobenzeprine: 1977

Tramadol: 1977 (Germany) 1995 (US)

Metoprolol: 1978

Captopril (first ACE inhibitor): 1981

Trazodone: 1981

Alprazolam: 1981

Glipizide: 1984

Bupropion: 1985

Buspirone: 1986

Zopiclone (first "Z-drug"): 1986

Lovastatin (first statin): 1987

Azidothymidine (first antiviral): 1987

Lisinopril: 1987

Fluoxetine (first SSRI): 1988

Omeprazole: 1989

Amlodipine: 1990

Sertraline: 1990

Gabapentin: 1993

Losartan (first ARB): 1995

Valacyclovir: 1995

Amphetamine/Dextroamphetamine (together as Adderall): 1996

Montelukast: 1998

Aripiprazole: 2002

Apixiban: 2012

[eisenkrahe]

I already keep track of a lot of this stuff but hey, it's useful.

[the-haiku-bot]

I already keep

track of a lot of this stuff

but hey, it’s useful.

Beep boop! I look for accidental haiku posts. Sometimes I mess up.

[byjove]

suspicious…

[catsblessing]

Could I potentially have some green and black decor based off like coding? Like yk the generic hacker stuff seen in like movies?

You make rlly cool decor and I’d love to have some featured in my spacehey or smth.. thank you!!!

yup =^-^=

[monidoll]

dna is often explained as if it was computer code, but its important to remember its literally a bunch of physical strings. just as important as the sequence itself is how these physical strings are packaged and where proteins attach to them, because this determines which parts can even be read

[monidoll]

purified dna looks like this in bulk

[rhapsodyxvi]

man what the fuck ever

[rhapsodyxvi]

like i get it. i get that these are logical names that mean things. but you can't just say "i'm installing numpy" and not expect me to do a double take. poob has it for you

[unification]

it's about being an instrument of truth by your own will. the guy who ingested helicobacter pylori to establish a clear causal link between it and the formation of gastric ulcers understood this too

[panvani]

Me and my bro in the 19th century inhaling and ingesting various chemicals just for fun

[historysurvivalguide]

“They say that he who would be its master must, little by little, inevitably become its slave”

- Lucifer (from da Bible) talking about learning science in the chemistry book I’m reading

[kaylmao]

has anyone seen my pet bacteriophage its name is styrofoam and its about [hand touching the floor] this tall

[bisexualbismuth]

Liveblogging working on my bioinformatics final project because otherwise I might explode.

[bisexualbismuth]

What on Earth is a JSON file.

[bisexualbismuth]

Ohhh, so it is some sort of unreadable horror. Okay, got it.

(Random microscope photo for size, etc.)

[bisexualbismuth]

Liveblogging working on my bioinformatics final project because otherwise I might explode.

[bisexualbismuth]

What on Earth is a JSON file.

[bisexualbismuth]

Liveblogging working on my bioinformatics final project because otherwise I might explode.

[fredersen]

a meba 🦠 is almost like a really really small anermal but not quite

[bisexualbismuth]

I ❤️ fungal sex

[bisexualbismuth]

Love working with eukaryotes, tbh. You can observe sooo much stuff without having to take out The Oil. "Oh, just buy a block of silk paper" No <3

[pinkblanc]

The Encyclopedia Americana, "Acute Tuberculosis", 1949

[bisexualbismuth]

Rhodotorula sp., lactophenol cotton blue, 40x // Prototheca wickerhamii

Rhodotorula sp. is a fungus that only causes disease in exceptional cases, mostly associated with immunosuppression. It is known by its carotenoid pigment, which causes the colonies to have a red-pink color. You can find basidoconidia on the photo if you squint.

Prototheca wickerhamii is an algae!! As you might guess, infections by algae are known as algaeosis, and by this organism in particular, as protothecosis. That segmented, wheel-like structure near the center is called a theca, and is where this species got its name from.