noise dept.
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Mike Driver
DEAR READER
wallacepolsom

roma★

shark vs the universe

★
Aqua Utopia|海の底で記憶を紡ぐ
taylor price

@theartofmadeline
tumblr dot com
Game of Thrones Daily
AnasAbdin
ojovivo
Misplaced Lens Cap

Origami Around
Keni
Sweet Seals For You, Always
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@egpunk
When I see ignorant idiots on Facebook start talking about the dangers of vaccines
When I hear people telling me that there is no way to over vaccinate my children and that they are completely safe and the medical industry would never work with food industry and political power handlers to create a trillion dollar disease profit crop…. Ignorance! Monsanto delivers foods knowing they create kidney failure…then buys massive shares in dialysis companies. Congressional acts signed by President Obama blanket protects Monsanto from any legal action and allows Monsanto to seize private farms. Monsanto is owned by Bayer - the largest pharmaceutical in the world…creater of vast quantities of vaccines…unnecessary vaccines.
Theres a huge Fuck-You difference between an MMR shot and requiring six…SIX tetnus ahora in order to enter the first grade. Telling me im a bad parent because I dont want give the “required” HPV vaccine to my 8 year old (violation of freedom of religion by the way - we teach our children abstinence) or guilting us to give our children vaccines for a from of Meningitis that only is found in Madagascar…fuck you!!!
I know what industry does… I work in it. I’ve seen the massive increase in cancer, the avalanche of kidney failure, autism 800% increase, bipolar, schizophrenia, ADHD…. By all means give your children over to those would crop them out…the same ones buying and selling harvests of dead unborn children bits.
Dont shame me with shallow “Toy Story” gifs….
Schizophrenic Spectrum of Disorders
Schizophrenic spectrum
Includes Schizoid personality disorder, Schizotypal personality disorder, Schizoaffective disorder and Schizophrenia. These conditions all have similar symptoms, such as a severely limited ability to make social connections along with a lack of emotional expression. —————————————————————————————-
Schizoid personality disorder is an uncommon condition in which people avoid social activities and consistently shy away from interaction with others. It affects more males than females. If you have schizoid personality disorder, you may be seen as a loner, and you may lack the desire or skill to form close personal relationships.
To others, you may appear somewhat dull or humorless. Because you don’t tend to show emotion, you may appear as though you don’t care about what’s going on around you. Although you may seem aloof, you may actually feel lonely, even if it’s hard for you to acknowledge. Or you may feel much more at ease being alone, and feel comfortable with your life.
The cause of schizoid personality disorder is unknown. Therapy and — in some cases — medications can help.
People with schizoid personality disorder are loners. If you have this condition, you’re likely to:
Prefer being alone and usually choose solitary activities
Prize independence and have few close friendships
Feel confused about how to respond to normal social cues and generally have little to say
Feel little if any desire for sexual relationships
Feel unable to experience pleasure
Come off as dull, indifferent or emotionally cold
Feel unmotivated and tend to underperform at school or work
Personality disorders begin in early adulthood, at the latest. Some of these tendencies may have first become noticeable during your childhood. They also occur across a range of social and personal situations. They may either cause you to have trouble functioning well in a job, socially or in other areas of life. However, you may do reasonably well in your job if you mostly work alone.
If you have schizoid personality disorder, you may not know how to form friendships, or you may feel too anxious around other people to try, so you simply give up and turn inward.
Are in touch with reality — they’re unlikely to experience paranoia or hallucinations
Make sense when they speak, although the tone may not be animated — in contrast to conversational patterns of someone with schizotypal personality disorder or schizophrenia, which are typically strange and hard to follow
————————————————————————————–
People with schizotypal personality disorder are often described as odd or eccentric and usually have few, if any, close relationships. They generally don’t understand how relationships form or the impact of their behavior on others. They may also misinterpret others’ motivations and behaviors and develop significant distrust of others.
These problems may lead to severe anxiety and a tendency to turn inward in social situations, as the person with schizotypal personality disorder responds inappropriately to social cues and holds peculiar beliefs.
Schizotypal personality disorder typically is diagnosed in early adulthood and likely to endure, though symptoms may improve with age. Medications and therapy also may help.
People with schizotypal personality disorder have difficulty forming close relationships and have peculiar beliefs and behaviors.
Schizotypal personality disorder signs and symptoms can include:
Being a loner and lacking close friends outside of the immediate family
Incorrect interpretation of events, including feeling that external events have personal meaning
Peculiar, eccentric or unusual thinking, beliefs or behavior
Dressing in peculiar ways
Belief in special powers, such as telepathy
Perceptual alterations, in some cases bodily illusions, including phantom pains or other distortions in the sense of touch
Persistent and excessive social anxiety
Peculiar style of speech, such as loose or vague patterns of speaking or rambling oddly and endlessly during conversations
Suspicious or paranoid ideas, hypersensitivity, and constant doubts about the loyalty and fidelity of others
Flat emotions, or limited or inappropriate emotional responses
Signs of schizotypal personality disorder, such as increased interest in solitary activities or a high level of social anxiety, may be seen in the teen years. The child may be an underperformer in school or appear socially out of step with peers, and as a result often becomes the subject of bullying or teasing.
Schizotypal personality vs. schizophrenia
Schizotypal personality disorder can easily be confused with schizophrenia, a severe mental illness in which people lose contact with reality (psychosis). While people with schizotypal personalities may experience brief psychotic episodes with delusions or hallucinations, they are not as frequent, prolonged or intense as in schizophrenia.
Another key distinction between schizotypal personality disorder and schizophrenia is that people with the personality disorder usually can be made aware of the difference between their distorted ideas and reality. Those with schizophrenia generally can’t be swayed away from their delusions.
Despite the differences, schizotypal personality disorder can benefit from similar treatments as schizophrenia and is sometimes considered a variant of schizophrenia. ————————————————————————————-
Schizoaffective disorder is a condition in which a person experiences a combination of schizophrenia symptoms — such as hallucinations or delusions — and mood disorder symptoms, such as mania or depression.
Schizoaffective disorder is not as well understood or well defined as other mental health conditions. This is largely because schizoaffective disorder is a mix of mental health conditions ― including schizophrenic and mood disorder features ― that may run a unique course in each affected person.
Untreated, people with schizoaffective disorder may lead lonely lives and have trouble holding down a job or attending school. Or, they may rely heavily on family or live in supported living environments, such as group homes. Treatment can help manage symptoms and improve the quality of life for people with schizoaffective disorder.
Schizoaffective disorder symptoms vary from person to person. People who have the condition experience psychotic symptoms — such as hallucinations or delusions — as well as a mood disorder. The mood disorder is either bipolar disorder (bipolar-type schizoaffective disorder) or depression (depressive-type schizoaffective disorder).
Psychotic features and mood disturbances may occur at the same time or may appear on and off interchangeably. The course of schizoaffective disorder usually features cycles of severe symptoms followed by a period of improvement, with less severe symptoms.
Signs and symptoms of schizoaffective disorder may include, among others:
Delusions — having false, fixed beliefs
Hallucinations, such as hearing voices
Major depressed mood episodes
Possible periods of manic mood or a sudden increase in energy and behavioral displays that are out of character
Impaired occupational and social functioning
Problems with cleanliness and physical appearance
Paranoid thoughts and ideas
——————————————————————————————
Schizophrenia is a severe brain disorder in which people interpret reality abnormally. Schizophrenia may result in some combination of hallucinations, delusions, and extremely disordered thinking and behavior.
Contrary to popular belief, schizophrenia isn’t a split personality or multiple personality. The word “schizophrenia” does mean “split mind,” but it refers to a disruption of the usual balance of emotions and thinking.
Schizophrenia is a chronic condition, requiring lifelong treatment.
In men, schizophrenia symptoms typically start in the early to mid-20s. In women, symptoms typically begin in the late 20s. It’s uncommon for children to be diagnosed with schizophrenia and rare for those older than 45.
Schizophrenia involves a range of problems with thinking (cognitive), behavior or emotions. Signs and symptoms may vary, but they reflect an impaired ability to function. Symptoms may include:
Delusions. These are false beliefs that are not based in reality. For example, you’re being harmed or harassed; certain gestures or comments are directed at you; you have exceptional ability or fame; another person is in love with you; a major catastrophe is about to occur; or your body is not functioning properly. Delusions occur in as many as 4 out of 5 people with schizophrenia.
Hallucinations. These usually involve seeing or hearing things that don’t exist. Yet for the person with schizophrenia, they have the full force and impact of a normal experience. Hallucinations can be in any of the senses, but hearing voices is the most common hallucination.
Disorganized thinking (speech). Disorganized thinking is inferred from disorganized speech. Effective communication can be impaired, and answers to questions may be partially or completely unrelated. Rarely, speech may include putting together meaningless words that can’t be understood, sometimes known as word salad.
Extremely disorganized or abnormal motor behavior. This may show in a number of ways, ranging from childlike silliness to unpredictable agitation. Behavior is not focused on a goal, which makes it hard to perform tasks. Abnormal motor behavior can include resistance to instructions, inappropriate and bizarre posture, a complete lack of response, or useless and excessive movement.
Negative symptoms. This refers to reduced ability or lack of ability to function normally. For example, the person appears to lack emotion, such as not making eye contact, not changing facial expressions, speaking without inflection or monotone, or not adding hand or head movements that normally provide the emotional emphasis in speech. Also, the person may have a reduced ability to plan or carry out activities, such as decreased talking and neglect of personal hygiene, or have a loss of interest in everyday activities, social withdrawal or a lack of ability to experience pleasure.
Inside the Brain: An Entire Head in Cross-Section
“The brain can get sick too.“
Re-make of this post.
End mental health stigma.
thank you
thank you
Crying
Bless you
Happy Halloween everyone.
(Image caption: A study by researchers at Tufts University School of Medicine discovered that astrocytes (fluorescing green cells) are a key element that link major brain receptors associated with learning and memory. Neurons are red)
Discovery of new pathway in brain has implications for schizophrenia treatment
Neuroscientists at Tufts University School of Medicine have discovered a new signaling pathway that directly connects two major receptors in the brain associated with learning and memory – the N-methyl-D-aspartate receptor (NMDAR) and the alpha 7 nicotinic acetylcholine receptor (a7nAChR) – which has significance for current efforts to develop drugs to treat schizophrenia. These findings demonstrate that astrocytes, a type of non-neuronal (or glial) cell once thought to have little part in brain information processing but now known to play important roles, are the key element that functionally links these two receptors.
The study, “Septal cholinergic neuromodulation tunes the astrocyte-dependent gating of hippocampal NMDA receptors to wakefulness,” is published in Neuron, May 4, 2017, online in advance of final publication.
“The NMDAR is the most investigated receptor in neuroscience because it is essential to synaptic plasticity, which is instrumental in establishing and remodeling brain circuitry and is thought to be the cellular foundation of learning and memory,” said Thomas Papouin, Ph.D., research assistant professor at Tufts School of Medicine and lead author of the study. “The NMDAR is known to be activated by two chemicals: glutamate, which is supplied by neurons, and D-serine, which is supplied by astrocytes. While most research is focused on the role that neurons play in activating the NMDAR via glutamate, we focused on the role played by astrocytes through the release of D-serine.”
Using in vitro and in vivo approaches in mice, the Tufts scientists found that astrocytes adjust their release of D-serine according to the degree of wakefulness of the mice. The astrocytes directly monitor wakefulness via the a7nAChR by sensing the level of ambient acetylcholine, a neuromodulator released in human and rodent brains during wakefulness. The more active the mice, the more D-serine is released by astrocytes, which allows a more robust activation of NMDARs. This was true even if researchers stimulated activity during times of day when mice are normally quiet.
“Astrocytes act like the dimmer control of a light,” Papouin said. “When the neuronal switch goes on, and glutamate is released, the setting of the astrocytic D-serine ‘dimmer’ determines the intensity of the NMDAR signal. During wakefulness, this dimmer is set on high – astrocytes provide a lot of D-serine – and this allows for a strong NMDAR signal. But during sleep or inactivity, it is set on low, allowing for a weaker signal.”
A New Framework for Treating Schizophrenia
The study offers a new functional framework for treating schizophrenia and opens fresh avenues for therapeutics and innovations in glial biology.
“This is an exciting finding with direct relevance to development of new treatments for schizophrenia, which is characterized by low levels of D-serine and diminished NMDAR as well as a major loss of cholinergic function. Efforts to develop pharmaceuticals to address these deficits have so far been unsuccessful, but in our study we were able to enhance NMDAR function via D-serine by stimulating a7nAChRs with a drug that has been part of recent stage 3 clinical trials for schizophrenia,” said Philip G. Haydon, Ph.D., corresponding author on the paper, the Annetta and Gustav Grisard professor and chair of the Department of Neuroscience at Tufts School of Medicine, and a member of the neuroscience program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts. “This suggests that cholinergic drugs now under development for schizophrenia work through this newly discovered astrocytic pathway.”
The study is the latest work from the Haydon group at Tufts, which focuses on astrocytes and the role they play in regulating synaptic transmission and neuronal circuits and in controlling behavior and disorders of the nervous system.
Seventeen years ago, the group introduced the “tripartite-synapse,” the first concept to acknowledge the role of astrocytes in the integration and processing of information at synapses. “In this paper we build on that concept to update our view of the role of astrocytes in computing information about the brain,” said Haydon. “Based on these findings and evidence recently published by others, we propose a new concept of ‘contextual guidance’ which incorporates how astrocytes tune synaptic activity to relevant global contexts by sensing the remote activity of neuromodulators such as acetylcholine and norepinephrine.”
WebMD of the North Star
For those of you that have taken STEP1
How many hours per day did you guys study during your dedicated period?
First Aid and UWORLD Journal today. Tomorrow begins 6 week dedicated.
Just Scheduled STEP1!
Its a weird feeling. I’m insanely nervous to take it, but I can’t wait for it to be over, so I can move on to clinicals.
😦 [#sketchscience]
Your blog is soooo cool ;)
Thank you! Tell me what you like and don’t like so I can improve.
Done with Comp
Finally done with the comp exam. Now I can finally leave and focus on STEP1 studying at home without any distractions.
Do you believe in ptsd in ems providers? There's some controversy about if ems providers jobs are radical enough to cause ptsd.
I strongly believe that there is PTSD in EMS providers, especially to varying degrees. I know for a fact that it is definitely a thing.
“Radical” enough?
I know this was probably meant to evoke a reaction such as this, but fuck it, I don’t care
Look at the body of a 10 year old child you couldn’t save. Is that radical enough?
Tell a woman who’s been married for 60 years her husband is dead and listen to her cry that she doesn’t understand. Is that radical enough?
Patch the bullet holes in an 18-year old gang banger. Radical enough?
See the result of a drunk driver who killed 3 people but doesn’t have a scratch. Radical enough?
Listen to the wails and cries of family when they find out their loved one is dead.
Respond to all the burns, gunshots, stabbings, domestic violence, cardiac arrests, suicides, attempted suicides, people who are choking on their own fluids who can’t breath and are TRYING to speak so that they can plead with you to save them. You tell me if that’s radical enough.
We all see terrible things. We all deal with it different ways. We all have THAT call, the one we can’t forget about. And we have THOSE calls, that go away but still come up every once in a while.
It’s not a matter of believing. PTSD in EMS providers is very, VERY real, and less well known than it should be.
Support each other, talk to someone.
Fact 👌🏼🙌🏼
I would like to say that people who think that ANYTHING, not just ems, is “not radical enough” clearly have no idea what PTSD is nor do they have even the slightest grasp on the concept of mental health.
LOL
STEP1 Resources
If anyone is approaching STEP1 study time and is unsure what resources they want to use, here is what I’m using.
First Aid + DIT as backbone (Rx videos when I’m just reading FA since I can’t focus for longer than 3 seconds at a time) Pathoma for Path (I also use Goljan for the blue notes in the margins and the diagrams, pictures, charts, etc) BRS for physiology Sketchy for Pharm & Micro Randy Neil MD videos on Youtube for Biostats (give them a watch for real, its 2 30-minute videos) Rx/UWORLD/Kaplan/NBMEs for Qbanks
It looks like a lot, but most of my review comes out of FA/DIT and Pathoma. The rest is supplementary when I need it. If you want my schedule, just shoot me a message. I’d be glad to help/give advice.