this is not a complete list by any means, but these commonly noted plants, herbs, and flowers should be handled with care or avoided altogether.
aconite (wolfsbane, monkshood) - all parts: dermatoxic, hepatotoxic, and neurotoxic
adam and eve (jack-in-the-pulpit, wild arum) - root: dermatoxic and gastrotoxic if ingested
african sumac - leaves: dermatoxic; possibly fatal
agave - juice: dermatoxic
angel’s trumpet - all parts: cardiotoxic; often fatal
apple - seeds: cytotoxic in large doses
apricot - leaves and seeds: cytotoxic in large doses
asparagus - berries: dermatoxic and gastrotoxic if ingested
azalea - all parts: cytotoxic and neurotoxic; rarely fatal
betel nut palm (pinyang) - all parts: gastrotoxic if ingested
bittersweet nightshade - all parts: neurotoxic and gastrotoxic; rarely fatal
black hellebore - all parts: cardiotoxic and gastrotoxic; possibly fatal
black locust (false acacia) - root bark and flowers: gastrotoxic
black nightshade - all parts except ripe fruit: neurotoxic and gastrotoxic; possibly fatal
bleeding heart - leaves and roots: neurotoxic
bloodroot - rhizomes: cytotoxic
blue passion flower (common passion flower) - leaves: cytotoxic
bracken - all parts: carcinogenic
buttercup - all parts: gastrotoxic and dermatoxic
calabar bean (ordeal beans) - seeds: neurotoxic and gastrotoxic if ingested in large doses
cassava - leaves and roots: cytotoxic in large doses
castor bean (castor oil plant) - seeds:cytotoxic if ingested or inhaled
cherry - leaves and seeds: cytotoxic in large doses
christmas rose - all parts: gastrotoxic
cocklebur - seedlings and seeds: gastrotoxic and neurotoxic
columbine - seeds and roots: cardiotoxic; easily fatal
corn lily (false hellebore) - all parts: cardiotoxic; often fatal
cowbane (water hemlock, snakeweed) - root: neurotoxic if ingested
daffodil - bulbs and stems: gastrotoxic; possibly fatal
datura/moonflower - all parts: gastrotoxic and cardiotoxic
deadly nightshade (belladonna) - all parts: cardiotoxic and neurotoxic; often fatal
desert rose (sabi star, kudu) - sap: cardiotoxic with skin contact
dumbcane - all parts: dermatoxic; possibly fatal
elder (elderberry) - root: gastrotoxic
elephant ear (angel wings) - all parts: dermatoxic and gastrotoxic
foxglove - leaves, seeds, and flowers: cardiotoxic; often fatal
garlic - all parts: gastrotoxic in animals
giant hogweed - all parts: dermatoxic
golden chain - all parts, especially seeds: neurotoxic and gastrotoxic; possibly fatal
goldenseal - all parts: gastrotoxic and neurotoxic in large doses
grapes/raisins - all parts: gastrotoxic in dogs
greater celandine - all parts: gastrotoxic in large doses
hemlock (spotted cowbane, poison snakeweed) - all parts: neurotoxic; possibly fatal
hemlock water dropwort - roots: neurotoxic if ingested; possibly fatal
henbane - all parts: neurotoxic and cardiotoxic
holly - berries: gastrotoxic
honeybush - all parts: gastrotoxic
honeysuckle - berries: gastrotoxic in mild cases and cardiotoxic in severe cases
horse chestnut - all parts: neurotoxic
hyacinth - bulbs: gastrotoxic and neurotoxic; possibly fatal
iris - rhizomes: gastrotoxic and dermatoxic
kava kava - nephrotoxic, hepatotoxic
kidney bean - raw: gastrotoxic
larkspur - young plants and seeds: neurotoxic; often fatal
lemon - oil: dermatoxic and gastrotoxic to animals
lily - all parts: nephrotoxic
lily of the nile (calla lily) - all parts: dermatoxic and gastrotoxic if ingested; possibly fatal
lily of the valley - all parts: cardiotoxic; possibly fatal
lima beans - raw: gastrotoxic
lime - oil: dermatoxic and gastrotoxic in animals
lobelia - all parts: gastrotoxic
mandrake - roots and leaves: gastrotoxic and neurotoxic
mango - peel and sap: dermatoxic
mangrove - bark and sap: dermatoxic and eye irritation
mayapple - all green parts and unripe fruit: gastrotoxic
meadow saffron (autumn crocus) - bulbs: gastrotoxic; possibly fatal
mistletoe - leaves and berries: gastrotoxic, cardiotoxic, and neurotoxic; rarely lethal in adults
moonseed - fruits and seeds: gastrotoxic; often fatal
mountain laurel - all green parts: gastrotoxic
nutmeg - raw: psychoactive in large doses
oak - leaves and acorns: gastrotoxic; rarely fatal
odollam tree (suicide tree) - seeds: cardiotoxic; often fatal
oleander - all parts: dermatoxic, cardiotoxic, and gastrotoxic; possibly fatal
onions - all parts: gastrotoxic in animals
orange - oil: dermatoxic and gastrotoxic in animals
peach - seeds and leaves: cytotoxic in large doses
periwinkle (vinca) - all parts: neurotoxic and potentially fatal
pokeweed - leaves, berries, and roots: gastrotoxic; often fatal
poison ivy/oak/sumac - all parts, especially leaves: dermatoxic; possibly fatal
poison ryegrass (darnel) - seeds: neurotoxic
privet - berries and leaves: neurotoxic and gastrotoxic; possibly fatal
ragwort - all parts: hepatotoxic
redoul - all parts: gastrotoxic, neurotoxic, and causes respiratory issues; can be fatal in children
rhubarb - leaves: nephrotoxic
rosary pea - seeds: neurotoxic and gastrotoxic; often fatal
spindle (spindle tree) - fruit: hepatotoxic and nephrotoxic; possibly fatal
stinging tree (gympie gympie) - bark and sap: dermatoxic; sometimes fatal
strychnine tree - seeds: neurotoxic; often fatal
sweet pea - seeds: neurotoxic and damaging to connective tissues
tomato - leaves and stems: cytotoxic in large doses
uva ursi - neurotoxic, dermatoxic
white baneberry (doll’s eyes) - all parts, especially berries: cardiotoxic; possibly fatal
white snakeroot - all parts: gastrotoxic; often fatal
winter cherry (jerusalem cherry) - all parts, especially berries: gastrotoxic; occasionally fatal, especially to children
yew (english yew, common yew) - leaves and seeds: gastrotoxic if ingested and respiratory issues if inhaled
glossary:
carcinogenic - a substance that can cause cancer
cardiotoxic - toxic to the heart
cytotoxic - toxic to living cells
dermatoxic - toxic to the skin
gastrotoxic - toxic to the gastrointestinal system (stomach, intestines, etc.)
hepatotoxic - toxic to the liver
nephrotoxic - toxic to the kidneys and urological system (ureters, bladder)
neurotoxic - toxic to the neurological system (brain, nerves, brainstem, spinal cord, etc.)
psychoactive - pertaining to substances that change brain function and result in alterations in perception, mood, or consciousness