Imagine unexpectedly popping up in Valhalla with your pants around your ankles because just half a minute ago you were taking a shit so bad that the Viking gods decided that it should count as dying in battle.
Isn't it even worse? You don't just pop up there. You get carried there by a Valkyrie.
You're experiencing a gastrointestinal event, and are really not having a good time, and the suddenly, without any logical way to be present there's a Winged Woman in there with you, in Armor, with Weapons and Helmet, who looks like she could take down Sandor Clegane or Geralt of Rivia in the 10 minutes before waking up, just plugs you from your porcelain throne and doesn't even gives you the chance to pull up your pants before carrying you off.
this 'being really tired after work' thing is really getting in the way of this 'pursuing my artistic hopes and dreams' thing has anyone else noticed this
Exclusive: Melbourne team demonstrates way to make the virus visible within white blood cells, paving the way to fully clear it from the bod
"A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells.
The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle.
Now researchers from the Peter Doherty Institute for Infection and Immunity in Melbourne, have demonstrated a way to make the virus visible, paving the way to fully clear it from the body.
It is based on mRNA technology, which came to prominence during the Covid-19 pandemic when it was used in vaccines made by Moderna and Pfizer/BioNTech.
In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.
Globally, there are almost 40 million people living with HIV, who must take medication for the rest of their lives in order to suppress the virus and ensure they do not develop symptoms or transmit it. For many it remains deadly, with UNAids figures suggesting one person died of HIV every minute in 2023.
It was “previously thought impossible” to deliver mRNA to the type of white blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the Doherty Institute and co-first author of the study, because those cells did not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.
The team have developed a new type of LNP that those cells will accept, known as LNP X. She said: “Our hope is that this new nanoparticle design could be a new pathway to an HIV cure.”
When a colleague first presented test results at the lab’s weekly meeting, Cevaal said, they seemed too good to be true.
“We sent her back into the lab to repeat it, and she came back the next week with results that were equally good. So we had to believe it. And of course, since then, we’ve repeated it many, many, many more times.
“We were overwhelmed by how [much of a] night and day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, ‘wow’.”
Further research will be needed to determine whether revealing the virus is enough to allow the body’s immune system to deal with it, or whether the technology will need to be combined with other therapies to eliminate HIV from the body.
The study is laboratory based and was carried out in cells donated by HIV patients. The path to using the technology as part of a cure for patients is long, and would require successful tests in animals followed by safety trials in humans, likely to take years, before efficacy trials could even begin.
“In the field of biomedicine, many things eventually don’t make it into the clinic – that is the unfortunate truth; I don’t want to paint a prettier picture than what is the reality,” stressed Cevaal. “But in terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing, in terms of how well we are able to reveal this virus.
“So from that point of view, we’re very hopeful that we are also able to see this type of response in an animal, and that we could eventually do this in humans.”
Dr Michael Roche of the University of Melbourne and co-senior author of the research, said the discovery could have broader implications beyond HIV, with the relevant white blood cells also involved in other diseases including cancers.
Dr Jonathan Stoye, a retrovirologist and emeritus scientist at the Francis Crick Institute, who was not involved in the study, said the approach taken by the Melbourne team appeared be a major advance on existing strategies to force the virus out of hiding, but further studies would be needed to determine how best to kill it after that.
He added: “Ultimately, one big unknown remains. Do you need to eliminate the entire reservoir for success or just the major part? If just 10% of the latent reservoir survives will that be sufficient to seed new infection? Only time will tell.
“However, that does not detract from the significance of the current study, which represents a major potential advance in delivery of mRNA for therapeutic purposes to blood cells.”"
My name is Abdelmajed.
I never imagined I’d be sharing my story like this, but life in Gaza has become unbearable. I am a survivor of the war here, and in the blink of an eye, everything I once knew—my home, my safety, my community—was ripped away from me.
The war has transformed Gaza into a graveyard of broken dreams. The buildings that once stood as symbols of life and resilience are now piles of rubble. Every corner is filled with the echoes of explosions. Every moment is shrouded in uncertainty. There is no security. There is no stability. There is no light at the end of the tunnel.
Basic needs have become luxuries.
Food is scarce. Clean water is even scarcer. Hospitals are overwhelmed and under-resourced, and there is almost no medical care to be found. Every night, families go to bed hungry, praying they’ll wake up to see another day. The cost of basic necessities has skyrocketed, and it’s become a daily battle just to survive.
I’ve seen things I never thought possible—standing in long lines for a piece of bread, rationing every drop of water, and watching my people suffer in silence. I have lost everything—my home, my safety, my dignity.
Escape from Gaza is my only hope,
but it’s almost impossible without financial help. The cost of evacuation is far beyond my means, and without support, I’m trapped in a warzone with no way out.
I’m reaching out to you now, in the hopes that someone, anyone, can help. I am not asking for luxury. I am asking for a chance—just a chance—to live. A chance to escape this never-ending cycle of fear, destruction, and loss. A chance to rebuild my life somewhere safe, where I can begin again, where I can find hope once more.
My name is Abdelmajed, and I am a survivor of the war in Gaza. Everything I once knew has been taken away—my home, my safety, and the people
Any amount you can give will help me get closer to safety.
Even the smallest donation will make a difference—it could be the lifeline I need to survive. If you are unable to donate, please share my story. The more people who hear it, the better the chance that I can find the support I desperately need.
Your kindness and support mean the world to me. You’re not just helping me escape a war; you’re giving me a chance to live, to rebuild, to breathe again.
This is the best representation of something I have been trying to explain to people for years!!!! Saving this to my phone so I can routinely pull it out when I need.
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