#aromatase

[azkarev521]

how my parents looked trying to come up with a name for me after I came out the womb as intersex (aromatase deficiency)

in Russia, typically surnames are feminine or masculine depending on the gender of the person. But my father wanted my middle name to be 'kareva' (fem vers. of Karev). So they decided to give me both fem and masc names, so they would call me Arabella-Anastasia Zanyia for fem or Karev for male.

However, I didn't end up being male, but I still kept Karev :))

[intersex-questions]

can you have both high e and t levels?

I don't think it's super common and it's not a topic I know a lot about, but I want to say that yes, it is possible. It's not something I managed to find a lot of information on, but I did find this (https://pubmed.ncbi.nlm.nih.gov/9856411/) research paper that mentions hyperandrogenism and hyperestrogenism occurring together in PCOS, although I do not have full access to the text. Generally speaking though, testosterone tends to lower estrogen levels, but high testosterone levels can cause higher estrogen levels because of the process of aromatization where aromatase catalyzes a reaction for testosterone to be converted into estradiol. In some cases, this can lead to hyperestrogenism. Estradiol is not converted into testosterone, though. So for some people, they might have what are considered high levels of both because that high T feeds into that high E. Someone please correct me if I am wrong though, I am not a biochemist and I am just someone with an interest.

[scriptlgbt]

I'm writing a story involving athetes. Is it less possible for trans men to dope with steroids? I mean testosterone is a steroid and taking too much will convert it back to estrogen instead of having the benefit of extra testosterone whereas when cis men take extra steroids they do get the extra benefits?

Cis men taking excessive testosterone do actually have it convert to estrogen eventually. I'm pretty sure this isn't unique to any body setup.

That said, there are other factors which can influence this. I'm not @scriptmedic so please don't take what I'm saying as gospel, I'm just a trans person who reads and googles. But I think it's aromatase (an enzyme) that converts testosterone to estrogen, and there are a lot of different things that can fuck with aromatase. Like being a smoker, or having uterine fibroids or something. Aromatase is found in gonads, but it's not exclusively found there. So I'm guessing whether you have gonads present can impact that too.

But I'm not sure about how it works in the specific case of taking an excess of testosterone. Again, I'm just a layman when it comes to this specifically, if somebody knows better, please please help explain.

For writing purposes though I would just assume this is the same across the board with trans men and cis men alike unless there's something different going on medically.

- mod nat

[bpod-bpod]

Hard as Nails

For the most common type of breast cancer, treatment often involves aromatase inhibitors (AIs), drugs which block oestrogen production. While initially effective, cancer can return, and when it does, the cancerous cells may be resistant to AIs, and may have spread by metastasis. Recent research suggests this could be because treatment with AIs causes epigenetic changes, modifications around DNA that alter how genes are transcribed, leading to an increase in keratin-80 (pictured, in purple, in an AI-resistant cancer cell surrounded by non-resistant cells, with cell nuclei in yellow). Related to keratins in hair and nails, this scaffolding protein makes cells stiffer, which could help them move and invade other tissues more easily during metastasis. While further studies are needed, these results suggest a link between resistance to AIs and increased metastatic potential, so targeting the resistance mechanism could be an effective route towards preventing future metastasis in breast cancer patients.

Written by Emmanuelle Briolat

Image from the Department of Surgery and Cancer, Imperial College London, London, UK

and the Division of Cancer Biology, Tumour Microenvironment Team, Institute of Cancer Research, London, UK

Image copyright held by the original authors

Research published in Nature Communications, May 2019

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[superpersonaenemy]

Does Testosterone Turn Into Estrogen When You Stop Lifting?

This is a common question, and the answer is not a simple “yes” or “no.” The relationship between testosterone, exercise, and estrogen is complex. Here’s a breakdown of how it works:The Conversion of Testosterone to Estrogen Aromatase: The key player in this process is an enzyme called aromatase. This enzyme is responsible for converting a portion of testosterone into a type of estrogen called…

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[ironpharma]

Proviron é útil ou inútil?

Nos dias que correm ainda são bastantes as dúvidas acerca do Proviron (Masterolona). Na realidade quando pensamos na sua capacidade anabólica, podemos concluir que e mesma é diminuta, e os seus efeitos a nível estético são escassos. No entanto a galinha dos ovos de ouro deste composto, acontece em duas ocasiões. Quando incluído intra ciclo e na terapia pós ciclo, a então famosa e chamada TPC.

Intra Ciclo

Por ter uma grande afinidade nos recetores de SHBG, o Proviron vai-se ligar nos mesmos, impedindo o SHBG de se ligar á testosterona livre, impedindo a mesma de se tornar uma testosterona ineficiente, fazendo com que a testosterona livre se torne eficiente e aproveitada pelo organismo. Além disso, pelo que sabemos ao dia de hoje, também se liga nos recetores de estrogénio sem os ativar, tendo também uma ligação na enzima aromatase, impedindo, ainda que de forma parcial, a conversão de testosterona em estradiol. Ou seja, a testosterona livre circulante no nosso corpo é aproveitada de forma mais eficiente, e consegue impedir ainda que de forma ligeira a aromatização.

 TPC ( Terapia Pós Ciclo)

Quando iniciamos uma TPC por muito eficiente e bem elaborada que a mesma seja, haverá sempre algum momento em que iremos sentir alguma queda de libido derivado ao nosso crash hormonal, pois chegará a altura que o nosso corpo deixará de ter testosterona que lhe era aplicada e nós através da TPC estamos a dizer para ele começar e voltar a produzir testosterona de forma exógena. Certo é que enquanto as nossas Gonadotrofinas (LH e FSH) não começam a trabalhar o mínimo desejável, e passamos por esse crash hormonal, o Proviron é um grande aliado pois nessas alturas a líbido poderá acusar esta desregulação hormonal. Ao incluir o Proviron em conjunto com os Serm´s na TPC, será um forte aliado para uma TPC bem efetuada passando pelo mínimo de privações e problemas possíveis. As doses poderão variar entre 25mg a 100mg dia. Existem relatos de uso de doses superiores. Será sempre tudo uma questão de necessidade individual.

Concluindo, faz todo o sentido, incluir o Proviron em qualquer ciclo, pois só trás vantagens, e não sendo uma droga hepatotóxica, o seu uso ajuda a prevenir problemas de aromatização e a aproveitar melhor a testosterona que estamos a aplicar.

De realçar ainda que embora seja um anabolizante oral o Proviron não é do grupo 17-alfa-alquilado mas sim metilado. Com isto significa que a sua passagem no fígado é menos agressiva, mas também por isso mesmo, os resultados anabólicos são diminutos. No entanto convém frisar que alterações das transaminases hepáticas (TGO/TGP/GGT) são sempre possíveis de acontecer.

Ao contrário dos outros esteroides anabolizantes Proviron é o único que não inibe o eixo HTP, por isso mesmo é e deve ser utilizado em Terapias pós ciclo.

[health-care-store]

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[medicomunicare]

Plotting against brain cancer at every cost: a committment for estrogens, enzymes and repurposed inhibitors

Plotting against brain cancer at every cost: a committment for estrogens, enzymes and repurposed inhibitors

Glioblastomas (GBM) are aggressive brain tumors that patients often are unaware of until symptoms emerge and the tumor is substantial. Current treatments include immediate surgery to safely remove as much tumor as possible, radiation and chemotherapy, but the tumor often recurs or becomes resistant to treatments. The average patient survives no more than 15 months after diagnosis. The drug…

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