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Long COVID patients can experience severe energy crashes after physical exertion. New research provides clear evidence that there's a biolog

Full Transcript at the link; 3-minute listen.

Quote:

By taking biopsies from long COVID patients before and after exercising, scientists in the Netherlands constructed a startling picture of widespread abnormalities in muscle tissue that may explain this severe reaction to physical activity.

Among the most striking findings were clear signs that the cellular power plants, the mitochondria, are compromised and the tissue starved for energy.

"We saw this immediately and it's very profound," says Braeden Charlton, one of the study's authors at Vrije University in Amsterdam.

The tissue samples from long COVID patients also revealed severe muscle damage, a disturbed immune response, and a buildup of microclots.

"This is a very real disease," says Charlton. "We see this at basically every parameter that we measure."

thatdiabolicalfeminist

I feel insane seeing stuff like this because this research already exists for Myalgic Encephalomyelitis, a post viral condition caused by multiple types of viral infections that a LOT of people with "Long Covid" meet the diagnostic criteria for.

This article mentions that ME/CFS is a "similar complex condition" but that's DEEPLY underreporting the similarities. The phrase "post exertional malaise" (now researchers are trying to replace it but this article uses that phrase) was INVENTED for ME/CFS. It's the only known condition, before "long covid", that causes these kinds of symptoms after exertion!

It's good to know for sure that it's the same mechanisms at play when the inciting viral infection is Covid and not, for instance, Epstein-Barr or RSV, but half the time it doesn't seem like researchers are making comparisons at all, just reinventing the wheel and acting like "long covid" is a totally new phenomenon with no previous point of comparison. There are literally drugs in human trials to try to treat the mitochondrial dysfunction in ME, this dysfunction is well-established and fairly well understood and I feel insane when ppl report on long covid without mentioning that there is already a named and studied condition that accounts for this subset of symptoms!!

SOME researchers are drawing comparisons but they're largely ME researchers who everyone else is largely cignoring because of the widespread perception that ME is a fake disease for lazy women.

That same perception btw is why "graded exercise therapy" (GET), or exercise gradually increasing in intensity, cwas for years the go-to treatment despite MOUNTAINS of evidence that it makes ME patients sicker. Some end up permanently bedbound and unable to even eat or drink without a feeding tube/IV because the damage is so bad! The GET recommendation was finally changed only in the past few years in the US and the UK, and many doctors hate that they're not allowed to recommend it anymore, because they insist despite the evidence that ME/CFS is psychological and ME patients are just "deconditioned" and too lazy to do anything about it.

Now the same kind of "treatment" is being recommended for long covid patients despite evidence showing exercise is having the same kinds of cellular effects as it does in ME patients. "Taking PEM into account" sounds gentler but I'm deeply concerned about the reinvention of GET for patients who meet all the criteria for an illness that's been shown definitively to become permanently worse with GET. This mitochondrial damage is progressive in ME, and there's no reason to believe patients who meet all the criteria of ME after Covid won't experience the same progression if they force themselves past their energy envelope in such a systematic way.

The additional finding that T cells — part of the immune system's arsenal — had infiltrated the muscles of long COVID patients also caught Iwasaki's attention, possibly indicating "an autoimmune response within the muscle cells."

This autoimmune response is well-researched for ME. Every time you overexert, you're injuring your cells more and more. It's deeply worrying that rebranded GET is being recommended for long covid patients who meet the criteria for ME when research like this study keeps showing it's the same phenomenon.

goth-queen

my-dailydreams

neurotypicalite

theres a pink blue and white flower at rhe grocery store i have to make. a joke

neurotypicalite

call that a transplant

fandomsandfeminism

This may be the best Pride merch I've seen from a major corporation.

Levi's said yes, actually. Assless chaps and a biker vest. Happy Pride.

And the assless chaps sold out on June 1.

aetherograph

They also specifically contacted members of the leather community, used them as models iirc, and donated $100k to Outright International. They talked the talk and walked the walk and put their money on it too. I don't really care that I can't afford and don't want this merch, I love to see my community getting the respect it deserves. Levi's said, "We make jeans which gays wear lots of jeans? Oh leather daddies? Let's call them."

fandomsandfeminism

I think Levi's donates to Outreach International every year too, as well as sponsoring pride events and other community support. They were offering Same Sex domestic partner benefits to employees in the 90s, and have been very public about their support for pro-lgbt legislation all through the 2000s.

So, you know, a giant corporation that walks the walk pretty consistently.

thecybercelestial

motherofcatsandmess

writerxwren

octaviaabadassblakee

I need fat female characters in tv whose weight is inconsequential. It means nothing to the story.

She's fat and gets the guy and no one bats an eye.

She's fat and the hottest chick in the sorority and that's normal.

She's fat and an actress and she gets good roles.

She's fat and she's funny and she has character depth and growth.

She's fat and the main character and no one mentions her weight once.

I'm fat and my weight doesn't play a part in my day to day conversations, or plans, or friendships. Why can't I have that on tv?

scorpionlafemme

gaypeople

“i’m in my 30s and i’ve made a best friend” i’m so normal and sane about this

naamahdarling

That has to be the most humiliating way to describe one of Earth's most terrifyingly effective predators.

sapphic-and-stupid

Picture of her from the USA Today

teaboot

I would let her kill me for sport

vaelus-malewife

shower-thoughts-last-responder

jxsmindoodles

Yes, I’ve heard your comments (and prayers) about Queen Siuan. Here she is in full regalia!

monstersholygrail

OH OH!! UPDATE!! A few weeks ago I mentioned going to on vacation and showing off my tits more which I was nervous about. But I’m HAPPY to report that it was a wild success. I felt extremely confident and happy with my body for a change. Plus I brought all the right vibes to the function: