If a person was dosed up on a cocktail mixture of venom and blockbuster serum; what strengths and weaknesses would the person gain from this empowerment? (I'm just asking for note purposes while outlining a fics first couple chapters.)
Well, there's been variations of both over the years.
Venom traditionally has a timeline of effect, so it's basically a comics steroid and the character bulks up massively and increases their strength/stamina/speed for a limited period, or while being delivered a dose (so Bane's hoses). Venom generally doesn't have any intellectual effects - it's basically just 'get roided up', though it's traditionally addictive, characters go through withdrawal after using it, might need to detox.
As a side effect of using it for so long, Bane's usually permanently affected to an extent by having taken so much Venom, but sometimes even he still shrinks down to his original build after using it. Colin Wilkes has a rare side effect where he can transform between the form of a grown up adult on Venom and his normal kid build at will, though given Colin doesn't get used much we don't know if that was temporary.
Blockbuster serum is a permanent effect (at least pre-2016, Seeley has Roland using it more like Venom). It also transforms characters into a super strong, brutish, 'roided up' version of themselves, like Venom, but it also made Mark (and Roland initially) extremely stupid. Mark couldn't even talk; Roland could when he used it. Roland ended up becoming highly intelligent via making a deal with Neron - it didn't have anything to do with the Blockbuster serum itself, it just fixed the problem he had.
Blockbuster serum is also extremely hard on your body; Roland has heart issues due to the strain of supporting his huge frame.
In the 2016 version that I've read so far, Roland has modified the chemical so he gets the boost temporarily, and so it also doesn't have the 'makes you stupid' aspect.
In terms of a combination of the two? The general increased strength and oversized muscles is the same for both. You'd need to decide if you want it to be a temporary or a permanent effect, and you'd also need to to decide if it affected the intelligence of the user. Personally for storytelling purposes if I wanted it to have weaknesses I'd keep the temporary effect and withdrawal symptoms from Venom, and the 'decrease intelligence' aspect from Blockbuster serum, though I probably wouldn't take the decreased intelligence to the 'mute brute' stage.
It might be interesting for the combination to have the opposite effect and BOOST intelligence during use, leading to even more reason to chase that high, and ever increasing withdrawal side effects and dependence, in tribute to how both Bane and Roland have used it over the years. It's just that this is not actually a known effect of either drug; it's just that Bane and Roland Desmond were both extremely intelligent characters to start with, and Roland specifically did a deal with a devil to be even MORE intelligent.
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