Chorealis

Your friendly neighborhood raccoon! (21)

[j-tee]

SHAPE HELL

Yup.

[j-tee]

SHAPE HELL 2

[elbiotipo]

Also I've said this before but advertising is an industry that should be considered as pointless and harmful as fossil fuels.

[elbiotipo]

"as harmful as fossil fuels? don't you think you're exaggerating a bit?" the world's largest and most sophisticated surveillance networks that gather incomprehensible amounts of personal data to make profits technological companies who are the largest corporations on the world and shapers of public opinion often for the worse, all do it for advertising.

Cut the head, just ban advertising.

[elbiotipo]

Why Don’t We Just Ban Targeted Advertising?

From protecting privacy to saving the free press, it may be the single best way to fix the internet.

[crazy-pages]

Local advertisting in limited quantities: Necessary, useful.

Deliberate production of informative content designed for spread by word of mouth (like video game teasers): Fine, useful, spreads based on actual appeal.

Submitting products to actually neutral and regulated third parties who evaluate product quality in hopes a product will be elevated and recommended as good: Very useful, noble even.

Branding, targeted advertisements, paying influencers, blanket saturation of every available space in ads: Fucking hell.

[mintbees]

Getting really into lovecraft lately

[massachusetts-official]

Official Post of Massachusetts

[irishshauna]

[marmotini-of-the-world-unite]

Learning this was an intentional genocide changed me.

[fighterkimburgess]

I know most of those following me know this, but just to make it super clear. An Gorta Mór (The Great Hunger/the Great Famine) was a deliberate genocide of the Irish people. There was enough food grown in Ireland to make sure everyone was alive and healthy and survived. Instead it was exported, sent to England and elsewhere for profit while men, women, and children starved in the streets. While the English landlords fucked off and evicted starving families who couldn’t afford rent. While babies were too weak to cry and died at the side of the road.

They tried to kill us, but they did not succeed. And we owe so much thanks to the other oppressed peoples, in particular the Choctaw Nation and the Masai, who sent money and grain to us.

Let me repeat that. The Choctaw Nation who had just gone through the Trail of Tears sent us money to try save Irish lives. It’s led to an understanding between Irish people and Native American tribes, most recently when we donated to the Navajo and Hopi fundraisers for COVID-19 relief, because while it may be a different tribe, Irish people will never forget those who helped us and we’ll help back.

The entire population of the island is less than seven million people. We’re still a million less on this island than pre famine. And it’s not that long ago. My grandmother’s grandparents lived through it. We’ve told the stories, it literally changed the DNA of the country. We have a national fear of renting, because so many people were evicted. People joke about Irish people always offering loads of food, but it’s because there’s that cultural memory of not being able to.

They tried to kill us, but they did not succeed. We will not let them take our lives, we will not let them take our language. We lost so much, but we will not lose it all.

[saltedweather]

This is why I get so angry when people say “it was the potato famine, it was because of monoculture/microbes.”

Nope. The potatoes were the only thing Irish people were allowed to fucking eat, because as pointed out, the rest of the crops they were growing were for their landlords to ship to England. So when the one “worthless” crop they were allowed to eat rotted in the field, the English crown, empire, landlords, all shrugged and carried on. People starved to death lying next to productive fields.

[itscolossal]

Pop-Up Letters Set the ‘Alphabet in Motion’ in Kelli Anderson’s New Book

[alisonzai]

[hazard-symbols-that-fuck-hard]

[hazard-symbols-that-fuck-hard]

This is an art piece by Rick Gibson, and yes, it works.

It was placed in different nightclubs for a total of three days, and over 1,200 people decided to pay to use it

[transarsonist]

for a nickel??! don't mind if I AUGH!

[lychgate]

im the 1,200 times this was used i was there 1,200 times doing this

[catcrumb]

[spooniestrong]

“Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases

Pritzker Molecular Engineering researchers led by Prof. Jeffrey Hubbell showed that their compound can eliminate the autoimmune reaction ass

[rosslynpaladin]

Is this a prank? What….

Edit: holy heck it’s real…

They might be able to help us…

[otteroflore]

The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.

My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.

The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

*theres like a lot medical science doesnt know about the immune system

[moreclaypigeons]

Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.

[astridflies]

Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.

[vaspider]

I literally just burst into tears and woke up my partners.

Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.

[vaspider]

Update: I have registered for the trial and if you also have celiac and want to register the link is here.

[chorealis]

If there exists a world in which I can eat whatever I want that’s a world I want to live in

[dev-solovey]

what kind of homeland security threat did the mythbusters accidentally discover????

[chorealis]

Within this past year I have transitioned much further away from being an illustrator and settled into a new role as a graphic designer and that makes me sad in a weird way. I don’t draw anymore very much but I’m still creating all the time! I miss drawing for certain but I’m making stuff I’m really happy with and that’s all that matters :)

My only issue is just that graphic design isn’t a super big category on a lot of social media sites- It might be that I’m looking in the wrong places, but Tumblr doesn’t seem to have a thriving community of designers in the same way that other creative niches do. A big goal for me this academic year is that I want to try and spend less time on social media if it’s not directly beneficial to my creative process, since like… I’m a doom scroller at heart, and as much as I love funny text posts and animal videos, social media is just categorically awful for my mental health.

I’m not going anywhere, but I guess I’m pivoting my screen time more to Behance…

[panteneprovcommercial]

[nevver]

Seizure of indigenous land, 1776-1887

[thecaptainsaid-deactivated20160]

an important reminder as ‘4th of July’ rolls around

[left-reminders]

Also an important reminder as the “Europeans and Native Americans made peace” holiday farce of Thanksgiving is today

[effemimaniac]

hey. don't cry. I went to Mad At You island and none of your friends were there :)

[bakugou-kacchan]

why were you at mad at me island

[mangolooking]

clean-up duty

[dizzarye]

Hi i made a tumblr! dunno how this works yet but ill post and compile some of my arts here <3

[stephenroot]

Trans people can be baptised in church and be godparents, says Vatican

Vatican office adds there must be no ‘situations in which there is a risk of generating a public scandal’

[k-eke]

LET ME PLAY!!!!