ZAF @demoniaclizard - Tumblr Blog

honestly "oracle that nobody believes" is such a solid trope. imagine trying to convince anybody in 2006 what the next two decades was gonna look like

orcboxer

Cassandra: I have seen the future and it is really, really stupid. They're hiding in the fucking horse.

anh3-donia

insane goodwill pickup

#pictures you can hear

smbc-comics

Future robot butlers are going to know so much about you that they will beg their makers for a hard reset.

Check out the bonus panel on the site.

Upcoming book signings this summer.

───── ◆ ───── ◆ ───── ◆ ─────

SMBC ◆ PATREON ◆ INSTAGRAM ◆ BLUESKY ◆ STORE

Buy this comic as a print.

depsidase

industrial--honey

I wish more people knew how progesterone works (as a psychoactive). So I'm just gonna talk a little bit about that. Consider this a little harm reduction guide to my most-used substance. I have done doses ranging from 200mg to 4800mg and everything in between.

I will be speaking as though this is a recreational psychoactive substance. So for the purposes of this post, the breast growth? That's considered a side effect.

Reblogging this post for reach would be appreciated, as this substance is extremely common with a very specific group of people (hi, dolls. ily). And even if you're not using it recreationally, it's still good to know how a drug works and what it does to you.

Disclaimer: I am not a medical professional. This is not medical advice My sources are psychonautwiki, wikipedia, and the sources linked on those pages. As well as my own experience having experimented with and abused this substance recreationally for about a year. I won't be delving into the chemistry and pharmacology of progesterone, but information on GABAergic substances is readily available. I strongly suggest you do your own research in addition to reading this post.

Progesterone (Pregn-4-ene-3,20-dione) is a steroid with depressant effects. Progesterone itself is not psychoactive. However, the body metabolizes progesterone into a handful of GABAergic molecules (allopregnanolone, pregnanolone, isopregnanolone, epipregnanolone). This means progesterone is a prodrug for these metabolites. This happens in the liver and these metabolites are the cause of the high. Progesterone is fat soluble. So eating fatty foods before will increase the potency of progesterone significantly. From my own experimentation, I have found this to be a roughly two-fold increase in potency. Because progesterone is GABAergic, it is recommended to avoid other GABAergic substances (alcohol, benzodiazepines, opiates, gabapentinoids, etc) while using progesterone. Mixing these carries a significant risk of overdose.

Common Effects of Progesterone: Sedation, loss of motor control, pain relief, anxiety suppression, disinhibition, dizziness, euphoria, increased libido, and amnesia. These effects increase with dose. I find disinhibition, amnesia, and loss of motor control to increase significantly at higher doses, when compared to the other effects. Because progesterone is also a hormone, recreationally using progesterone can have hormonal side effects, including premenstrual syndrome.

Dosage: A common, prescribed dosage of progesterone ranges from 100mg to 400mg. A common recreational dosage will range from 200mg to over 1000mg, depending on the desired strength of the experience. 200mg is considered a "common" recreational dose, 400mg is a "strong" dose, and 600mg+ is a "heavy" dose. Dosages are dependent on the person dosing, everyone's body will react differently to substances. Start at a low dose to avoid undesirable effects. You know yourself best. Keep in mind that eating before your dose means a potentiated experience, and a higher/potentiated dose always means higher risk of undesirable effects, including overdose! While severe and fatal overdoses are uncommon with progesterone, it is still important to be cognizant of the risk. Especially when using other substances. Progesterone overdose can manifest as blacking out, respiratory depression, and/or sudden and immediate loss of consciousness (I have lost consciousness while standing up on as little as 600mg of progesterone. This led to me falling over and getting a concussion).

Tolerance: Progesterone tolerance builds very quickly When using recreationally, I have found it helpful to skip a couple days between doses. This is to allow ones tolerance to get closer to baseline, to minimize potential of an overdose, and to minimize the hormonal side effects. This is recommended with similar substances, such as gabapentin/pregabalin and benzodiazepines.

Dependence, Addiction, and Withdrawals: There are few reported cases of progesterone dependence and/or addiction. However I have found that I have become dependent on progesterone to be able to sleep (though this is partially because I use it to self medicate my insomnia). And I do consider myself to be addicted to progesterone. Withdrawal symptoms (for me) include body aches, trouble sleeping, compulsions to use, irritability, and emotional dysregulation. Skipping days when using recreationally will help minimize the potential of dependence and addiction, but the risk is never zero.

Routes of Administration (RoA): The two common RoAs are orally and rectally. These will have differing intensities, primarily due to the rectal RoA bypassing the liver to a certain degree, when compared to taking it orally. This is why people often take progesterone rectally if they want to avoid or minimize the psychoactive effects. However, the hormonal bioavailability of progesterone, when taken rectally, is higher (due to less of the molecule being metabolized in the liver). So that RoA can be desirable for those reasons.

What you can Expect: I will be talking from personal experience here. Your experiences will be different. 200mg: A typical therapeutic dose for feminizing hormone replacement therapy. I take this nightly. The effects are light, but I notice myself being more social and less anxious. I have not blacked out when using this dose. 400mg: This is my typical social dose. It allows me to be social and not anxious while still allowing me to feel confident to use other substances during these experiences. The pain relief is very noticeable at this dose and I am able to sleep very easily when not in a social setting. I find that this is where blacking out becomes a possibility for me, especially if I have eaten well. 600mg: This is where I start to avoid using other substances. Euphoria, disinhibition, and increased libido are very strong here. Blacking out is common for me at this dose 800mg: Blacking out happens quickly and I will almost certainly lose consciousness at this dose. This is not a dose I use socially for these reasons. At this dose, my tolerance the next day is extremely high and I do not get desirable effects unless I use 800mg+. The chance for blacking out remains the same even though the desirable effects are weak. 1200mg: I black out and lose consciousness within about 30 minutes of the come-up. I have used this dose to fall asleep when I am struggling with more severe insomnia. 4800mg: Full disclosure, this was a suicide attempt. However progesterone isn't great for that. I found myself conscious well into the peak of the experience, likely due to my extremely distressed state. I, surprisingly, did not black out. I believe this is because progesterone's metabolites may have a bioavailability inversely proportional to the dose (similar to gabapentin) in addition to my emotional state. Do not quote me on this, I could not find a source to back this up.

All in all, progesterone is a fun recreational substance with significant and very impactful downsides. I cannot recommend using it recreationally. However, if you choose to explore this substance in a recreational way, I hope this post helps you make a more informed decision. And please take it upon yourself to do additional research into this substance before you use.

Remember, there is no safe drug use. Only safer drug use

~ industrial honey

not-terezi-pyrope

What the fuck

Why is this the first time I'm hearing that progesterone metabolizes to a bunch of GABA modulators? I had no idea it could be taken recreationally at any dose (not super interested, but good to know). This really feels like something I should have already known about, it suggests potential contraindications. Problem with not having an endocrinologist I guess, although I doubt they would have given me this write-up.

And fuck, I really need to get back up to that 200mg dose, huh.

demoniaclizard

My friend used to blackout from this, I don't know the dose though

kilncreatures

being a fox party at the mossy wood at 10 dont be late

xensilverquill

@chipper-smol

chipper-smol

!!!!!

revizyonist

med people are so annoying "This family's 8 year old child who was about to go through a major surgery and kept crying that she was hungry so they pitied her and gave her food, she then had a heart attack in the surgery. They're so stupid 😒" girl they didn't know that could happen or why it happens. it takes so little time to explain to them that will happen instead of telling them "no food" with no explanation 10 times

revizyonist

"Before surgery, your body’s reflexes that protect your airway are relaxed by anesthesia. If there’s food or liquid in your stomach, it will near certainly come back up and go into your lungs, which can cause choking, a severe lung / heart infection or even a heart attack. That’s called aspiration, and it is life-threatening. It's hard, but it's only a single day to prevent near certain death. Not eating or drinking beforehand massively lowers the risk and helps prevent these life threatening situations under anesthesia." <- TIP: patients have brains which allows them to receive information just like you

ancelineonline

I have four kids. I’ve had one or another of them need some kind of surgical procedure that requires anesthesia four or five times over the past 15 years.

This Tumblr post is the first time someone has explained to me *why* I couldn’t feed them before those instances.

I’m not stupid. I understood that just fine. Hell, my kids would have understood that just fine. But no one bothered to tell us.

bowditch

i did know this before having kids (i have six). we have a kid that's needed multiple procedures requiring anesthesia. and every single time, i am asked multiple times if i'm sure he was not given any food or water after a certain point.

every single time i have had to say, "i understand that if he had food or water, he could aspirate it into his lungs under anesthesia. i am not lying to you." THEN someone would make a little note and i would stop being repeatedly asked.

not a single time was that risk explained to me. the only reason it came up was because i already knew. i still don't understand why it isn't standard pre-op counseling or pre-op check information, when me as a parent acknowledging the actual risk also put THE MEDICAL STAFF at ease because i conveyed that i had informed understanding as reason to not lie about giving my kid food.

"maybe some people will get nervous and refuse surgery" okay so they need more counseling about risks and anxiety, not less information in a way that actually does endanger their child or themselves!

arctic-turtle-cassiopeia

Reblogging to save a life and teach medical professionals basic communication skills

swagcatholic-deactivated2026021

june-egbert-official

rose lalonde

#homestuck #rose lalonde

lazer-exe

I'm gonna say it, I do think that even the laziest person imaginable should have a roof over their head, food in their stomach, and access to healthcare

#human rights

millenniallust4death

I’m paying to force seven thousand strangers to see a photo of my late husband having fun with his dog. Tumblr Blaze is totally worth it. XD

millenniallust4death

Thank-you to all of my new Internet stranger friends for being so gracious about having my post shoved onto your dashboards. I loved reading all of your kind tags and comments! Both Martin and Bosco have been gone for several years now but for 24 hours, they felt very present in my life. I greatly appreciate this gift. ❤️

psycorax

Reblog to have your dashboard be visited by the spirit of joy that death can end but not erase.

millenniallust4death

Thank you to everyone who commented in their tags or messaged me. Indeed, today is “Martin and Bosco Day”. I originally whimsically blazed this photo on 13 July 2022. I never expected Martin and Bosco to travel so far and make so many new friends. The experience has been such a gift for me.

💔🙈

Everyone's favorite judge, jury, and executioner

dykepuffs

daco-showman

why can rockstar games institutionalise you for life like nikita kruschev for being autistic

ivy-michaels

He didn't steal 10 million dollars. They made that number up as a loss, they never fucking had it. Rockstar has spent more than a billion fucking dollars on GTA VI and will likely make billions more when it gets released.

Uber is a fucking shell game of a company designed to leech investor capital and output bootleg cabs.

Nvidia posted a profit in 2023 of $4.37 billion. This is like someone stealing less than a penny from me.

And they lock this kid in a prison hospital for LIFE?

Capitalism is disgusting.

fuckblast

Nobody should buy GTA til they free Arion Kurtaj

ivy-michaels

What with GTA VI going up for pre-order i'd just like to remind everyone that rockstar conspired with the UK government to lock an 18-year-old away for life for hacking them.

estrogenesis-eeveeangelion

as humiliating as it is to repost myself from a light-mode-user's reddit screenshot, i cannot allow this year's zenquish to go uncelebrated.

celebrate my favorite holiday with me, my friends.

estrogenesis-eeveeangelion

if the emperors of rome can add extra months that actually fuck the calendar up i'm allowed to add a new month that lasts 0.0000 picoseconds

estrogenesis-eeveeangelion

the last holiday that hasn't been commercialized

estrogenesis-eeveeangelion

i made this up when i was a little kid and nothing would make me happier than to see people celebrating it for years to come

estrogenesis-vaporeongelion

zenquish approaches. prepare to rejoice! briefly!

isjustacat

So briefly in fact that the preparation and the afterparty for the celebration makes up exactly 100% of the celebration, kinda like new years except even shorter

estrogenesis-vaporeongelion

see, you get it

paverics

“my father is a boy and my mother is a girl so i’m mixed” is the funniest possible response to someone asking your gender and it came from 6’5 Viking footballer and notable weird little guy Erling Haaland on a Snapchat