Origami Around
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we're not kids anymore.
Today's Document
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祝日 / Permanent Vacation
PUT YOUR BEARD IN MY MOUTH
RMH
cherry valley forever
izzy's playlists!
Three Goblin Art
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occasionally subtle
Product Placement
Not today Justin
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@transcontext-blog
Problems that you solve for aesthetic value only, just to create something beautiful, turn around and turn out to have some application in the real world. …and as weird and surprising as it may sound …origami may someday be used to save a life.
Robert Lang
TED Talk Video: http://www.ted.com/talks/robert_lang_folds_way_new_origami
(AKA: So I learned how to make a heart stint from my 4th grade substitute teacher.)
Break it down! Never to soon, too late to #dance
Why can't the world's greatest minds solve the mystery of consciousness?(Re: The Guardian, The Long Read @oliverburkeman )
This one might not be for solving in the key of explicit analysis, much as questions of sustainability in a world decidedly hostile to pervasively broad, deep, sustained sustainability. Our language, our science, our ways of seeing and connecting will give way to something more implicitly capable: space to let things BE (as they might be, whole-like). There's where consciousness clicks: it might be a collaborative, dynamically balanced ever-self-creating art.
The way that the brain’s internal maps are linked and anchored to the external world has been a mystery for a decade, ever since 2014 Nobel Laureates May-Britt and Edvard Moser discovered grid cells, the key reference system of our brain’s spatial navigation system. Now, researchers at the Mosers’...
We make our own realities && might be more reflective together #neuroscience #research #perception
TNG #Valentine for the inspiring @Marina_Sirtis @akaWorf @Gates_McFadden @SirPatStew @BrentSpiner #atElAdrel!
Merry Saturday, peoples! #afro #freckles #beauty #photo
(Image caption: Alterations of the human 16p11.2 chromosomal region lead to a variety of cognitive disorders, including autism. Credit: Pasieka/Science Source)
New findings reveal genetic brain disorders converge at the synapse
Several genetic disorders cause intellectual disability and autism. Historically, these genetic brain diseases were viewed as untreatable. However, in recent years neuroscientists have shown in animal models that it is possible to reverse the debilitating effects of these gene mutations. But the question remained whether different gene mutations disrupt common physiological processes. If this were the case, a treatment developed for one genetic cause of autism and intellectual disability might be useful for many others.
In a paper published today in the online edition of Nature Neuroscience, a research team led by Mark Bear, the Picower Professor of Neuroscience in MIT’s Picower Institute for Learning and Memory, showed that two very different genetic causes of autism and intellectual disability disrupt protein synthesis at synapses, and that a treatment developed for one disease produced a cognitive benefit in the other. The research was performed by postdoc and lead author Di Tian, graduate student Laura Stoppel, and research scientist Arnold Heynen, in collaboration with scientists at Cold Spring Harbor Laboratory and Roche Pharmaceuticals.
Researching the role of fragile X syndrome
One heritable cause of intellectual disability and autism is fragile X syndrome, which arises when a single gene on the X chromosome, called FMR1, is turned off during brain development. Fragile X is rare, affecting one in about 4,000 individuals. In previous studies using mouse models of fragile X, Bear and others discovered that the loss of this gene results in exaggerated protein synthesis at synapses, the specialized sites of communication between neurons.
Of particular interest, they found that this protein synthesis was stimulated by the neurotransmitter glutamate, downstream of a glutamate receptor called mGluR5. This insight led to the idea, called the mGluR theory, that too much protein synthesis downstream of mGluR5 activation gives rise to many of the psychiatric and neurological symptoms of fragile X. Bear’s lab tested this idea in mice, and found that inhibiting mGluR5 restored balanced protein synthesis and reversed many defects in the animal models.
Different genes, same consequences
Another cause of autism and intellectual disability is the loss of a series of genes on human chromosome 16, called a 16p11.2 microdeletion. Some of the 27 affected genes play a role in protein synthesis regulation, leading Bear and colleagues to wonder if 16p11.2 microdeletion syndrome and fragile X syndrome affect synapses in the same way. To address this question, the researchers used a mouse model of 16p11.2 microdeletion, created by Alea Mills at Cold Spring Harbor Laboratory.
Using electrophysiological, biochemical, and behavioral analyses, the MIT team compared this 16p11.2 mouse with what they already had established in the fragile X mouse. Synaptic protein synthesis was indeed disrupted in the hippocampus, a part of the brain important for memory formation. Moreover, when they tested memory in these mice, they discovered a severe deficit, similar to fragile X.
Restoring brain function after disease onset
These findings encouraged the MIT researchers to attempt to improve memory function in the 16p11.2 mice with the same approach that has worked in fragile X mice. Treatment with an mGluR5 inhibitor, provided by a team of scientists at Roche led by Lothar Lindemann, substantially improved cognition in these mice. Of particular importance, this benefit was achieved with one month of treatment that began well after birth. The implication, according to Bear, is that “some cognitive aspects of this disease, previously believed to be an intractable consequence of altered early brain development, might instead arise from ongoing alterations in synaptic signaling that can be corrected by drugs.”
Current research indicates that well over 100 distinct gene mutations can manifest as intellectual disability and autism. The current findings are heartening, as they indicate not only that drug therapies might be effective to improve cognition and behavior in affected individuals, but also that a treatment developed for one genetic cause might apply more broadly to many others.
In graphic novels, ancient mythology, comic books, and other media, we find characters who, when killed or otherwise injured, bounce back. Some of these characters habitually bounce back as stronger, faster, or with new abilities & talents. While many who struggle with injury or wonder about the potential or nature of healing dream to learn the secrets of super-recovery, maybe there is no secret. Hint from an older school: maybe these characters are manifestations of elemental "investment" or "reservation" for some unknowable circumstance... instances of the prototypical seed, in which untold breadth, depth, growth, and impact are implicitly and partly woven in a "lesser" package. The rest of that potential might then be woven in the seed's environment: the nature; the nurture; the nourishment; the toxicity; the sun. Across dimension and scale, time and concept, whether of form or simply, for instance, an idea... these characters can be said to have always been more than they were depicted to be, even more than they knew themselves to be. Some of them know, and choose to be lesser, for a time, out of consideration for what comes, what must be, and the proverbial writing on the wall that might guide the way between the musts through the might-yets. I suspect that we might not all be created equal and this is part of the resilience of life itself. I also suspect that, while we marvel at super-depictions of vaguely-human characters and archetypes, each of us, even the "least" of us is a seed more meaningful and -- in perhaps a not-so-familiar-sense -- purposeful ...than the "wisest" of us is likely to ever word or prove. Let's sow ourselves (and each other) with care; maybe necessarily for now: we know not what we do.
If you like talented #graff && #stickers creatives check out @cist_ones on IG. Let @bomit know #CIST might just win this #stickerartistoftheyear #stickerbombing #vote #talent #BK #BROOKLYN
If @bluebottle #oakland hadn't kicked me out over #prejudice, I'd go back someday and introduce friends and business assocates to these glammy concoctions. d'oh! Much more on this later.
#latergram from #brainwash in #SF. No doubt on some level I processed this in choosing my dryer. And it works for me #TARDIS LIFE.
At #Brainwash in #SF and my disgustingly #adorable #uglydoll victim is ...having a blast. My #soft #blue recipient of UNTOLD #TERROR #mouahahahahahahar seems to enjoy all the inappropriately delicious #food and diverse lifestyle-business mashuls #here. #BigToe's lack of apparent disdain for my intended abuses and will to #torture BigToe with quality #coffee products and absurdly #refreshing perspectives on what's possible in #business, #life, and #love... well, I wonder if I'm #doingItWrong. @floraexplora apparently I fail at #evil and I'm done blaming other people and #pillow-like beings ostensibly born of fluff and quirk and maybe joy. Maybe I've been living a lie? @uglydollusa, did you bring these things to earth to undermine us wouldbe-evildoers and our precious #cocktails of spite and apathy (neat, double, no #lime)??? I'm so torn! Bluetooth suggested to be left on the washer for "good vibes" and all I can think about is... what if there is something to this #madness... this...#good??? I am so #lost. 😠😢😥😟😵😔😓🙈🙉🙊💩 (at Brainwash Cafe)
Daily Show correspondent Michael Che tries to find a safe place to report from.
Ouch. Another case where the #comedians might be onto something here.
When you find something you love on Pinterest, sometimes you want to learn more so you can act on baking those cookies, streaming that movie, or buying that couch. That’s why we’re taking a first step toward making pins more useful. We’re also making it easier to pin no matter where you are.
Pinterest introduces more useful pins.
kind of a big deal ;-B
TEDxCERN will be held inside CERN’s world-famous Globe. Photo: TEDxCERN
You have probably heard of CERN — the European Organization for Nuclear Research and the home of the Large Hadron Collider (LHC), the world’s largest and most powerful particle accelerator: longer than the island of...
In digital advertising, there is no secret that relevance is a crucial variable to success. But it takes more than relevance to see the high engagement rates marketers seek. Chris Dixon thinks about digital advertising in more than just two buckets; brand awareness and direct...
How Animals Eat Their Food
