Nitty Gritty Oh So Pretty

Sanguine, INTP, book-connosieur, geeky-nerd, sapiosexual, secret-life living, romantic, rebel and 3rd year medical student trying to explore science, aesthetics, and pushing through the status quo. This is my catch-all study and misc blog.

[callese]

refseek.com

www.worldcat.org/

link.springer.com

http://bioline.org.br/

repec.org

science.gov

pdfdrive.com

[theleoisallinthemind]

Wind Cathedral, Namibia by photographer Paul Godard

[jaubaius]

These ‘Beach Animals’ were created by Theo Jansen as a fusion of art and engineering. The kinetic structures walk on their own and get all their energy from the wind.

[vintrkraka]

fuck it, straandbeast saturday

[grittynityohsopretty]

Not mine. Found on reddit.

[everythingstarstuff]

Caitlin Keegan

[michaelmoonsbookshop]

Leather bound books from the 19th century with gilt detailing 

[grittynityohsopretty]

Rounding in the wards. *sigh*

[greatmindquotes]

We must walk consciously only part way toward our goal, and then leap in the dark to our success. - Henry David Thoreau

[everythingfox]

“Now THAT’S how you quarantine”

(via)

[whitepeopletwitter]

[thesaltyoncologist]

Seconded.

[doctorofwhut]

I don’t want all these signs calling me a hero. I want systemic change.

[medxclusive]

USMLE Review: Tay-Sachs disease

medXclusive Learning

Other Names: GM2 gangliosidosis, type 1; HexA deficiency; B variant GM2 gangliosidosis; Hexosaminidase A deficiency; Hexosaminidase alpha-subunit deficiency (variant B); Sphingolipidosis, Tay-Sachs; TSD; Gangliosidosis GM2, type 1

[Cherry-red spot as seen in the retina in Tay–Sachs disease. The fovea’s center appears bright red because it is surrounded by a whiter than the usual area.]

Mnemonic: Tay-Sachs Testing recommended (If both parents are identified as carriers) Autosomal recessive Young patients (< 4 years of age) Spot in the macula (Cherry red macula) Ashkenazi Jews (Most common) CNS degeneration / Chromosome 15 HEXA gene mutation/ Hexosaminidase A deficiency Storage disease (GM2 Gangliosidosis)

Tay-Sachs disease is a rare inherited disorder that progressively destroys nerve cells (neurons) in the brain and spinal cord. The most common type, known as infantile Tay–Sachs disease, becomes apparent around three to six months of age with the baby losing the ability to turn over, sit, or crawl. This is then followed by seizures, hearing loss, and inability to move. Death usually occurs in early childhood. Less commonly the disease may occur in later childhood or adulthood. These forms are generally milder in nature.

Mutations in the HEXA gene on Chromosome 15 cause Tay-Sachs disease. The HEXA gene provides instructions for making part of an enzyme called beta-hexosaminidase A, which plays a critical role in the brain and spinal cord. This enzyme is located in lysosomes, which are structures in cells that break down toxic substances and act as recycling centers. Within lysosomes, beta-hexosaminidase A helps break down a fatty substance called GM2 ganglioside.

Mutations in the HEXA gene disrupt the activity of beta-hexosaminidase A, which prevents the enzyme from breaking down GM2 ganglioside. As a result, this substance accumulates to toxic levels, particularly in neurons in the brain and spinal cord. Progressive damage caused by the buildup of GM2 ganglioside leads to the destruction of these neurons, which causes the signs and symptoms of Tay-Sachs disease.

Because Tay-Sachs disease impairs the function of a lysosomal enzyme and involves the buildup of GM2 ganglioside, this condition is sometimes referred to as a lysosomal storage disorder or a GM2-gangliosidosis.

The diagnosis of Tay-Sachs disease involves a blood test that detects absent or very low levels of beta-hexosaminidase A enzyme activity. Molecular genetic testing of the HEXA gene may be used to identify the specific mutations present or to rule out the disease if a false-positive blood test result is suspected. Currently, there is no cure for Tay-Sachs disease, and there are no therapies that slow the progression of the disease. 

[autumncottageattic]

[grittynityohsopretty]

Not mine. Found on reddit.

[unexplained-events]

Researchers have used Easter Island Moai replicas to show how they might have been “walked” to where they are displayed.

VIDEO

[smileforthehigh-deactivated2017]

Finally. People need to realize aliens aren’t the answer for everything (when they use it to erase poc civilizations and how smart they were)

[desiremyblack]

(via TumbleOn)

[pearlsnapbutton]

What’s really wild is that the native people literally told the Europeans “they walked” when asked how the statues were moved. The Europeans were like “lol these backwards heathens and their fairy tales guess it’s gonna always be a mystery!”

[kiwianaroha]

Maori told Europeans that kiore were native rats and no one believed them until DNA tests proved it

And the Iroquois told Europeans that squirels showed them how to tap maple syrup and no one believed them until they caught it on video

[theopensea]

Oral history from various First Nations tribes in the Pacific Northwest contained stories about a massive earthquake/tsunami hitting the coast, but no one listened to them until scientists discovered physical evidence of quakes from the Cascadia fault line.

[thegirlthewolfate]

Roopkund Lake AKA “Skeleton Lake” in the Himalayas in India is eerie because it was discovered with hundreds of skeletal remains and for the life of them researchers couldn’t figure out what it was that killed them. For decades the “mystery” went unsolved.

Until they finally payed closer attention to local songs and legend that all essentially said “Yah the Goddess Nanda Devi got mad and sent huge heave stones down to kill them”. That was consistent with huge contusions found all on their neck and shoulders and the weather patterns of the area, which are prone to huge & inevitably deadly goddamn hailstones. https://www.facebook.com/atlasobscura/videos/10154065247212728/

Literally these legends were past down for over a thousand years and it still took researched 50 to “figure out” the “mystery”. 🙄

[archaeologistforhire]

Adding to this, the Inuit communities in Nunavut KNEW where both the wrecks of the HMS Erebus and HMS Terror were literally the entire time but Europeans/white people didn’t even bother consulting them about either ship until like…last year. 

“Inuit traditional knowledge was critical to the discovery of both ships, she pointed out, offering the Canadian government a powerful demonstration of what can be achieved when Inuit voices are included in the process.

In contrast, the tragic fate of the 129 men on the Franklin expedition hints at the high cost of marginalising those who best know the area and its history.

“If Inuit had been consulted 200 years ago and asked for their traditional knowledge – this is our backyard – those two wrecks would have been found, lives would have been saved. I’m confident of that,” she said. “But they believed their civilization was superior and that was their undoing.”

https://www.theguardian.com/world/2016/sep/16/inuit-canada-britain-shipwreck-hms-terror-nunavut

“Oh yeah, I heard a lot of stories about Terror, the ships, but I guess Parks Canada don’t listen to people,” Kogvik said. “They just ignore Inuit stories about the Terror ship.”

Schimnowski said the crew had also heard stories about people on the land seeing the silhouette of a masted ship at sunset.

“The community knew about this for many, many years. It’s hard for people to stop and actually listen … especially people from the South.”

 http://www.cbc.ca/news/canada/north/sammy-kogvik-hms-terror-franklin-1.3763653

[crazythingsfromhistory]

Indigenous Australians have had stories about giant kangaroos and wombats for thousands of years, and European settlers just kinda assumed they were myths. Cut to more recently when evidence of megafauna was discovered, giant versions of Australian animals that died out 41 000 years ago.

Similarly, scientists have been stumped about how native Palm trees got to a valley in the middle of Australia, and it wasn’t until a few years ago that someone did DNA testing and concluded that seeds had been carried there from the north around 30 000 years ago… aaand someone pointed out that Indigenous people have had stories about gods from the north carrying the seeds to a valley in the central desert.

[fluffmugger]

oh man let me tell you about Indigenous Australian myths - the framework they use (with multi-generational checking that’s unique on the planet, meaning there’s no drifting or mutation of the story, seriously they are hardcore about maintaining integrity) means that we literally have multiple first-hand accounts of life and the ecosystem before the end of the last ice age

it’s literally the oldest accurate oral history of the world.  

Now consider this: most people consider the start of recorded history to be with  the Sumerians and the Early Dynastic period of the Egyptians.  So around 3500 BCE, or five and a half thousand years ago These highly accurate Aboriginal oral histories originate from twenty thousand years ago at least

[ironbite4]

Ain’t it amazing what white people consider history and what they don’t?

[gluklixhe]

I always said disservice is done to oral traditions and myth when you take them literally. Ancient people were not stupid.

[zizicat]

[laterovaries-deactivated2017022]

This will always be my favorite gifset. Ever.

[onceuponamirror]

im morally obligated to reblog this every time i see it

[findingfeather]

Atheist nurse wins fight to end mandatory 12-step addiction treatment for health staff in Vancouver | CBC News

Health-care professionals who work in Vancouver-area hospitals and medical clinics will no longer be required to attend 12-step programs if they want to keep their jobs after being diagnosed with addiction.

GUYS THIS IS HUGE. 

THIS IS ACTUALLY REALLY HUGE. IN A VERY GOOD WAY. 

[kawuli]

SUPPORT EVIDENCE-BASED ADDICTION TREATMENT NOT RELIGIOUS AUTHORITARIAN ORGANIZATIONS

[anais-ninja-bitch]

“While many people say AA has been instrumental in their recovery from addiction, scientists have long questioned the overall effectiveness of the program, and say choice in treatment plans is key to recovery.”

THISTHISTHISTHISTHISTHISTHIS

[quotemadness]

“I am selfish, private and easily bored. Will this be a problem?”

— Neil Gaiman