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@theartofmadeline

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macklin celebrini has autism
I'd rather be in outer space 🛸
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2025 on Tumblr: Trends That Defined the Year

if i look back, i am lost

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$LAYYYTER
One Nice Bug Per Day
EXPECTATIONS
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@mirahimage
I will not hide this
god cursed me into seeing this image so im making it everyone elses problem
How could you do this to poor Risk Astley?
I know this is from Australia but when I first saw the words “Victorian man” all I could think of was this:
To be fair imagine you just arrived in 2018 from Victorian England and discovered Take On Me, what are you supposed to do, not blast it loud enough for your family to hear it all the way back in 1876?
Betrayed and backstabbed by your scheming evil advisor? Psch. Skill issue. Absolute amateur problem. Just hire two of them and reward them for snitching on each other. Just make sure that neither of them is gay or they'll just end up hate-fucking each other and fucking you over all the same.
"hire two evil advisors but make sure neither of them is gay" are you hearing yourself right now. be serious
clowngirl getting an orchiectomy and the surgeon just keeps removing ball after ball after ball after ball after
clown nurse standing by solemnly adding each successive ball to the ones she's already juggling
is there a point if I don't pass?
Nobody passes reliably. It's always contextual and conditional. Transvestigators think Margot Robbie is a brick. Is there a point to Margot Robbie's womanhood? Should she abandon it? And then what? Dress butch? Take testosterone? Get sweaty and cumbrained and swole? And she wears a strapon? And she makes you suck the strap? Is that the kind of world you want to live in? One where boymoder Margot Robbie makes you suck strap?
THIS IS THE HARDEST I HAVE LAUGHED IN SO LONG YOU HAVE CURED MY DEPRESSION
This is one of the greatest posts I’ve ever witnessed. The payoff was amazing.
My roommate heard it going and went “OH MY GOD is it EVER going to resolve?” then the payoff hit and she busted up laughing
When I say women should have higher standards for how they're treated, this is exactly what I mean. At the first insult? Kick. Him. To. The. Curb.
Some great additions from the comments.
Writing tips:
“You feel the bulge in his pants” - implies that you are feeling some guy’s penis, may be sexy depending on context
“You feel the bugle in his pants” - implies that this guy has a military horn in his pants, invites confusing questions like why does he have that and how big are his pockets
Both options convey that he's horny
How dare you be funnier than me on my own post
someone on reddit shared texts of her and her husband's exclusive english dialect and it's beautiful
a linguist is analyzing it
official linguistics post
Him getting smaller and smaller as he walks up to the truck is some real Peter Jackson The Lord of the Rings forced perspective movie magic
Happy Gandalf gets to lick a graham cracker Monday
The Chinese shoe manufacturer decided to demonstrate the indestructibility of their shoes
And also the indestructibility of that woman's ankles
are you guys hearing about this dude working to developing a vaccine for cats that he's hoping would like. theoretically double their lifespans?
turns out i wasn't making that up, his name is Dr. Toru Miyazaki! he also wrote a book called "The Day Cats Live To Be Thirty", so cats are kind of his thing.
apparently, cats' kidneys tend to be the thing that takes them down, something about their bodies being unable to self-clean their kidneys, and the vaccine is supposed revitalize the body's ability to do just that. It would be very VERY fucking cool to have cats suddenly reaching 30 years of age be the normal thing.
As they age, almost all cats develop kidney disease, from which they eventually die. Just as in humans, kidney disease i
Dr. Toru Miyazaki’s AIM injection for cat kidney disease enters trials in 2025, aiming for a 2027 release. Greycoat Research supports the sc
whoa wait i actually read the articles and it's so much cooler than just that!!
dude cracked the case about WHY kidneys fail, across the board as far as i can tell. turns out there's a specific molecule whose job it is to attach to waste and signal macrophages to come eat it. it remains inactive in cats for some reason, but the molecule is still there. basically what he's done is found the switch to activate them. this will be profound not only for our domestic babies, but for big cats too - especially cheetahs!
although his research was focused on cats, it's already being used to develop drugs for humans too!
on top of that, since these molecules are tags for waste, this could also dramatically lower the rate of fatty liver disease, liver cancer, urinary crystals, rheumatoid arthritis, and even some neurological cases! like, they're hoping it may have an impact on parkinson's and alzheimers, but it DOES have an impact on stroke recovery. like. holy shit.
furthermore, he's insisting that the feline drug be affordable if and when it rolls out onto the market. he wants this to be something anyone can get for their cat!! idk how much sway he'll have over the human drug, but hopefully enough that it, too, won't be that expensive.
annnnnd in his research that he's still doing for the human side of things, he's found a potential link between this molecule and estrogen. in the 20,000 samples he's tested, women between ages 10 and 29 had the highest amount of this molecule present in their blood (a higher amount means Something Fucky is going on, essentially. There's a higher amount of waste the body is trying to clean out) but it drops down to be almost equal amongst men and women after menopause. it hasn't been looked into yet, but fuck, just the fact it's noted and known and probably WILL be looked into soon??? imagine if this is what leads to figuring out all the various ways the ovaries and uterus fucks with people and how to fix it. or even like, maybe there's something about estrogen that makes it work better. who knows! but it's rad the link is there to be researched :D
man just think, not only could our kitties start living longer, healthier lives, but just maybe dialysis will become as rare and obsolete as the iron lung is for people. what a badass Dr. Toru is!
"But I don't want to turn people into dinosaurs. I wanna cure kittie kidneys!"
Update: So they have done clinical trials and have submitted it for approval as of april 2026. They are expecting it to be available late 2026/early 2027
The AIM protein drug for feline chronic kidney disease has been submitted for approval in Japan (April 2026). We break down clinical trial d
As for the study itself, the 360 day follow up on stage 3 kidney failure kitties showed that the control had a survival rate of about 20%, while the test group had a survival rate of 80%
New 2026 study: AIM protein boosts cat kidney disease survival from 20% to 80%. Discover how this scientific breakthrough is changing the fu
Our cat Scout is in the early stages of kidney disease. This might be available in time to save her!