#chemokine

[dr-afsaeed]

C-X-C chemokine receptor type 4 (CXCR4) antagonism in precision oncology: Clinical applications and future directions - Research

Physiologically, the C-X-C chemokine receptor type 4 (CXCR4) signalling pathway regulates key aspects of tumor behavior (growth, metastasis, and immune evasion) and modulates immune system function. Anticancer researchers have identified peptide-based CXCR4 antagonists as promising candidates due to their high targeting specificity and favorable safety profiles. This review provides an analytical…

[dr-afsaeed]

The MicroRNA miR-223 Constrains Colitis-associated Tumorigenesis by Limiting Myeloid Cell Infiltration and Chemokine Expression

Abstract Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression is observed in CAC, it is also unclear how myeloid-specific microRNAs impact the inflammatory process that underpins the…

[medicomunicare]

All hands on DECs: lift your skin up 'cause immunity won't TLR8 further X-age-rated IFNrence

Scleroderma or systemic sclerosis (SYS) affects approximately 300,000 people in the U.S., with about one-third developing systemic disease, which can affect major organs such as the lungs, kidneys or heart. Women are four times more likely than men to be diagnosed with the disease, but until now, the underlying reason for this gender disparity had remained elusive. Two new studies led by…

All hands on DECs: lift your skin up 'cause immunity won't TLR8 further X-age-rated IFNrence

[medicomunicare]

Breast cancer shift toward evil-ution: replacing growth factors with chemokines-to-thrive

Breast cancer affects about 10% of women in their lifetime and is a serious medical and social burden. Fewer treatment options are available for breast cancers that lack estrogen receptors and therefore do not respond to hormone therapy. Breast tumors that lack not only ER-alpha, but also the EGFR tyrosine kinase receptor and the progesterone receptor, are particularly difficult to treat. They…

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[medicomunicare]

Spondylobjection sustained: finally the guilty MIF got framed by some molecules

Spondylobjection sustained: finally the guilty MIF got framed by some molecules

Axial spondyloarthritis (AxSpA), a painful and debilitating form of arthritis that affects 1% of Canadians and causes inflammation of the spine, joints, eyes, intestines and skin. Currently against this is a devastating disease, which has a serious impact on the quality of life, doctors have a very limited arsenal. Although several treatments, including biotherapies, have been approved for AxSpA,…

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[blogsillygivercollection-blog]

C-C Chemokine Receptor Type 1 Report by Material, Application, and Geography

[doctipster-blog]

3-D Structure of Chemokine Receptor Facilitates Drug Discovery

3-D Structure of Chemokine Receptor Facilitates Drug Discovery

A new chemokine receptor study offers new drug development approaches for autoimmune and inflammatory diseases. Inflammation reactions in our bodies fight against infections; however, too much of these reactions may result in cancer or autoimmune diseases.  To reduce inflammation, scientists rely on CC chemokine receptor 2 (CCR2), a protein which plays a significant role in inflammation. CCR2…

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[healthinnovations]

Researchers identify protein responsible for post-viral asthma in young children.

Researchers identify protein responsible for post-viral asthma in young children. Thoughts health innovators?

Researchers at the Medical College of Wisconsin (MCW) have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children.

Asthma is a chronic disease of the airways that affects more than 300 million people worldwide. It is the number one…

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