given the current climate this pride especially i feel i must mention that i love my trans friends, i stand with trans people in the fight against transphobic legislation and those who would enforce it, and this blog is not a good place for you to be if you do not vibe with that
For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again
For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again tomorrow.
That routine just changed.
On March 26, 2026, the U.S. Food and Drug Administration approved Awiqli (insulin icodec-abae), developed by Novo Nordisk, as the first and only once-weekly basal insulin ever approved for adults with type 2 diabetes in the United States.
This is not a minor update to an existing drug.
It is the first entirely new class of basal insulin to reach U.S. patients in more than two decades.
Instead of injecting insulin every single day, people with type 2 diabetes using Awiqli will only need one shot per week, on the same day, every week.
That means reducing from 365 injections a year down to just 52.
For anyone who has ever felt the weight of that daily ritual — the anxiety of forgetting, the physical discomfort, the constant reminder that their body needs help — this approval represents something much bigger than a dosing schedule.
It represents relief.
How the Drug Actually Works
Understanding why this injection lasts a full week requires a quick look inside the body.
Most traditional basal insulins are absorbed into the bloodstream and begin breaking down within 24 hours, which is why patients need a fresh dose every day to maintain stable blood sugar levels.
Awiqli works differently.
Its active ingredient, insulin icodec-abae, is engineered to loosely attach to a blood protein called albumin, which is found naturally and abundantly in the bloodstream.
This attachment creates a slow-release reservoir.
Instead of flooding the system and fading fast, the insulin releases gradually and consistently over an entire seven-day period, keeping blood sugar in a healthy range around the clock...
What Comes Next
Awiqli is not standing alone in this space for long.
Eli Lilly is developing its own once-weekly basal insulin, called efsitora alfa, which is currently in late-stage clinical trials.
If that drug also earns FDA approval, it would give patients and doctors two once-weekly options to choose from, allowing for personalized decisions based on a patient’s health profile, insurance coverage, and individual response.
The broader direction of travel in diabetes care is unmistakable.
Fewer injections, smarter formulations, and better integration with digital tools like continuous glucose monitors and insulin-tracking apps are all converging toward a future where managing diabetes requires less daily mental effort without becoming any less medically precise...
A Small Shot With Large Implications
It is easy to look at a once-weekly injection and see only a scheduling change.
But the science behind Awiqli, the scale of the ONWARDS trials, and the consistent satisfaction reported by patients all point toward something that matters far more than convenience.
Diabetes management has always asked a lot of people.
It asks for daily vigilance, daily discipline, and a daily willingness to confront one’s own condition, sometimes in uncomfortable or inconvenient circumstances.
Anything that reduces that load, without reducing the quality of care, is worth taking seriously.
For the more than 37 million Americans living with diabetes, and the hundreds of millions more around the world, a simpler weekly routine could mean the difference between a treatment plan that works on paper and one that actually works in a person’s life.
That is the real significance of what the FDA approved on March 26, 2026.
Not just a new drug.
A new way of keeping people healthy, one week at a time.
The other night husband and I were watching a documentary about the yeti where they were doing DNA analysis of samples of supposed yeti fur, and every one of them came back as bears.
Anyway, the next night we watched a thing about some pig man who is supposed to live in Vermont. People said it had claws and a pig nose but walked upright like a man. Now, I happen to know that sideshows used to shave bears and present them as pig men. So every piece of evidence they gave of this monster sounds to me like a bear with mange.
So now the running joke in our house is that everything is bears. Aliens? Bears. Loch Ness monster? Bear. Every cryptozoological mystery is just a very crafty bear.
Bears. They’re everywhere. Be wary. Anyone or anything could be a bear.
As the OP of this post, I’m going to threaten that if this gets to one million notes by the 10 year anniversary on 1 June 2026, one year from today, I will get a lower back tattoo of the loch ness bear monster.
person who works at some sort of superhero agency or otherwise fights for the good of others, who likes to flip a coin every now and then to see if the animation's gotten better, and if it does, they stop doing whatever task they were previously on to go join in on the upcoming fight.
excerpt:
"Agent 7, why did you start running into oncoming traffic?! We need you to finish filing your incident reports!"
"Frame rate's better."
"...What?"
"Animation picked up, there's a fight happening."
"Ok-- Agent 7? Where are you?"
"South district, there's motion blur now."
"South dis... THAT'S 20 KILOMETERS AWAY! HOW DID YOU MOVE THAT FAST?!"
"Timeskip. Animators did the running with the foreground blocking me so that I would be closer to the scene in a shorter amount of time. Also the camera's panning now."
"For fuck's sa-"
And then the operator would call for backup or something
Me: "Damn people are REALLY BAD at knowing when to tag their eyestrain art/images...either that or they just don't care about photosenitive epileptic people like me. I feel really sad now."
Person: "But Allison, what if they just don't know or understand what qualifies as eyestrain and what doesn't?"
Me: "You know what? That could be a factor...While it is always better to be safe rather than sorry (so YES people should always tag eyestrain even if they're unsure if it "counts" or not) maybe you've got a point?"
Anyways! HERE'S YOUR HANDY GUIDE TO WHAT CAN COUNT AS EYESTRAIN! I'm pulling this straight from the Artfight rules page about what needs to be labeled and filtered as eyestrain because it's VERY helpful and VERY accurate! I also know not everybody has an AF account and might not always have access to this handy guide, and this is an important resource; That's why I'm sharing it here! (under the cut)
PLEASE TAKE THIS SERIOUSLY!!! THIS IS ABOUT THE HEALTH AND SAFETY OF OTHERS!!!
Full eyestrain AF page link
"But Allison! How were you able to screenshot that example if you're so sensitive to eyestrain?"
I dimmed the HELL out of my computer screen and looked away while taking the screenshot and did the same when putting it into this post, that's how lol. BUT YEAH ANYWAYS!!! Once again:
PLEASE TAKE THIS SERIOUSLY!!! THIS IS ABOUT THE HEALTH AND SAFETY OF OTHERS!!!
“If I had time travel I’d kill Hitler” “If I had time travel I’d stop my favourite politician getting assassinated” you’re all thinking way too small. If I had time travel I’d stop Neil Armstrong and Buzz Aldrin from dying on the moon due to Soviet sabotage, kicking off the Great Nuclear War and devastating half of the planet.
This is such a classic trainwreck post that has the vibes of a 2014 screenshot posted to Pinterest and then the last addition is just last Tuesday I can’t even
[ID: Screenshot of the tiktok message from ndssorg that reads: This #World Down Syndrome Day (spaces for readability), we've joined forces with @/coordown and other international Down syndrome organizations to spread the powerful message: No Decision Without Us. 💪
People with disabilities deserve a seat at the table where decisions are made about their lives, their futures, and their rights. Let's work together towards a world where every voice is valued. # No Decision Without Us #WDSD25 /End ID]
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