I feel like one Superhero verse that was extremely well developed was City of Heroes.
Yeah, it was built to be a video game setting, but you had all the genre conventions, so that all the genre conventional threats were covered.
Circle of Thorns was the magic conspiracy. Crey Industries was the evil science corporation. Nemesis was the “plans within plans super planner” type. Malta Operatives brought in the evil superhero registration act types while not invalidating the friendly “on the side of justice” feel you had. Knives of Artemis were basically cat burglar mercenaries aesthetic, even though they were actually assassins. And there were plenty of superpowered street gangs ranging from Skyway City to Atlas Park.
And, of course, there was Praetoria, your “the main hero group is evil in this parallel dimension” group, which was pretty cool to face off against.



















