
izzy's playlists!
Show & Tell

No title available

No title available
YOU ARE THE REASON

祝日 / Permanent Vacation
Alisa U Zemlji Chuda

⁂
noise dept.
Sade Olutola

Discoholic 🪩
wallacepolsom
$LAYYYTER
i don't do bad sauce passes
Aqua Utopia|海の底で記憶を紡ぐ
we're not kids anymore.

tannertan36
KIROKAZE

PR's Tumblrdome
h

seen from New Zealand

seen from United States

seen from Malaysia

seen from Australia

seen from United States
seen from Germany
seen from United States
seen from Spain
seen from United States
seen from United States
seen from United States
seen from Australia

seen from United States
seen from United States

seen from United Kingdom
seen from Germany
seen from Germany
seen from United States
seen from Spain
seen from United States
@talkatave
Perfectly matching and replicating colors just by seeing them is an art, and, while it's also a very useful task, people who can do this are primarily artists.
Massimo / X
Wow.
Yeah but no but yeah -- Look he didn't just colour match it, he also added in the turbulence medium, the clearcoat and the correct metallic flecks... for a paint that will dry a lighter shade than when it goes on.
That's like being served an entire thanksgiving meal made my one person in 45 minutes and then saying "Oh they made me a snack": It is radically underselling what this person can do.
this is skill to the point of witchcraft, this is Mastery
What is the funniest pokemon move
Obsessed with the description for this move
Post corrections/clarifications are my favorite genre of humor: a compilation
okay let's bake a cake 🎂
butter
sugar
eggs
flour
milk
baking powder
vanilla extract
This artist's rendition is like a renaissance painting and is the most thing I've ever seen (affectionate) thank you for your service
Is this ready for @hellsite-hall-of-fame yet?
Happy Anniversary Vanilla Sweep
it’s been a whole year since vanilla extract?!???
Age-old advice which is more relevant nowadays rather than less. This is the second iteration of it though. The original version is: “Never write anything in a letter you wouldn’t want to see in print.” Advice handed down by my mother from her forbears.
From the IT department. We archive EVERYTHING. And Outlook autosaves every couple seconds.
“Dance like no one is watching. Email and text like it will one day be read in court.”
nintendo: can't have alcohol in our child gambling games!!! solution???
vacation juice
Me after consuming nineteen (19) glasses of vacation juice:
Get cocooned
its so unfortunate when different peoples neurodivergent traits clash horribly. like yes i totally understand that the man at the other table cant control his stimming and loud vocal tics and i think he deserves to have a nice day out at a restaraunt without judgement. however if i dont remove myself from the audible vicinity in the next 20 seconds i will explode.
The people who police your gender will police your gender even if you're cis.
Eat them.
"OH those body builder women with pancake breasts arent-" eat them.
"This woman has a beard, thats not-" eat them.
"That man has a baby face, that's not" - eat them with barbecue sauce.
Eat them. You will never be gender enough for their definition of gender. Eat them.
this is EXACTLY my mom's texting vibe, please have my favourite screenshot of my mom's texts ever that's a fan favourite with my friends
you forgot the best part tho
(via @butchmuppet)
no lie, the second half of this post really helped me put a different perspective on my life and greatly the decreased the anxiety i have about my life to come
Spoopy Season Safety
Oh my god reblog to save a me thank you
Reblogging even though it's way past Halloween bc this is an important reminder!
Stay away from anything with activated charcoal during this season if you are on ANY medication!!!
[ID 1: Alice & Boogles HEELS ON WHEELS (@Wooden_MariaGO) said: PSA... During the spooky season, you may be tempted to get something with activated charcoal in it because it looks cool - BUT!! if you're taking medications, it may weaken the medication! Especially important to consider with something like birth control! #charcoal. The photos show a black latte, a black ice cream and a black drink with ice cubes. End: ID 1]
[ID 2: 'student loans (@sydsowlheap) said: For everyone on HRT, activated charcoal FLUSHES it out of your system. PLEASE stay away from it! This includes T, E, and birth control, as well as most medications. Be safe!! If you're making something for someone, just use black sesame paste, squid ink, or artificial colour. End: ID 2]
requested by @dante-doofenschmirtz
RATING: MOSTLY RELIABLE
It is correct that activated charcoal (AC) can affect the absorption of drugs taken by mouth.
From the ScienceDirect overview on activated charcoal: 'In general, activated charcoal can reduce the absorption of and therapeutic response to other orally administered drugs.'
It's a bit of a oversimplification to say that activated charcoal 'flushes it out of your system', but the general gist is right. The activated charcoal adsorbs the drug in the digestive system, and prevents it from being absorbed into the blood. Instead it passes through the the digestive tract with the AC.
From The Encyclopedia of Toxicology: 'Charcoal is neither absorbed in the gastrointestinal (GI) tract nor metabolized. Due to its large surface area, it absorbs chemicals in the GI tract, trapping and carrying them out of the body without allowing them to be absorbed into the blood.
When it comes to drugs not taken orally, things get a bit more complicated. I have not been able to find any research on activated charcoal and HRT specifically, but I have found some other information that I will compile here.
A Business Insider article on activated charcoal suggests that only oral birth control is affected by AC, and other forms are not. However, Business Insider is only considered Mostly Factual according to MBFC, so I would not consider this as strong evidence.
From the Business Insider article: 'Dweck recommended leaving at least two hours between your pill and big doses of charcoal, like you might find in supplements or products included in "cleanse" diets.
And remember that this warning applies only to birth control pills you ingest: The effectiveness of the IUD, the implant, the NuvaRing, the shot, and the patch won't be affected by charcoal in the stomach.'
The Science Direct overview also suggests that, when AC is administered in a hospital setting, other medications can be given as long as they are not given orally. This would suggest that non-oral medications are not significantly affected by AC.
From the ScienceDirect overview on activated charcoal: 'When concomitant drug therapy is needed, drugs can be given parenterally if activated charcoal has been administered'
However, it should be noted that AC prevents drug absoprtion in two different ways:
1. It adsorbs drugs when they enter the stomach, before being absorbed into the blood.
2. It adsorbs drugs that are circulating back into the gastrointestinal tract from the liver, a process known as enterohepatic circulation.
Whilst drugs which aren't taken orally will not be affected by the first method, some could theoretically be affected by the second.
From the paper The effect of activated charcoal on drug exposure following intravenous administration: A meta-analysis: 'AC reduces drug exposure via two distinct mechanisms. It diminishes primary drug absorption by binding drug in the gastrointestinal tract. It also enhances drug elimination by interrupting enterohepatic circulation or by binding drugs that have been reintroduced into the gastrointestinal tract, by passive or active transport (enteroenteric circulation).5 Since the two mechanisms overlap, they are difficult to distinguish from each other.'
I located a list of compounds that are theoretically in enterohepatic circulation, and therefore could be affected by AC in this manner. This list includes Estradiol, Estrone, and Testosterone.
From Enterohepatic circulation: Physiological, pharmacokinetic and clinical implications: 'Table II lists examples of compounds reported to be excreted in the bile and therefore possibly available for enterohepatic recycling.'
In conclusion, I could not find specific evidence on how AC affects HRT when not taken orally. Some evidence suggests it would not be significantly affected, whilst other evidence does suggest a theoretical mechanism in which AC may affect non-oral drugs.